聚羟基脂肪酸酯(PHAs)基止血材料研究进展  

Research Progress on Polyhydroxyalkanoates(PHAs)-based Hemostatic Materials

作　　者：吴远东 郑维爽 李源遽 都贝宁 张兴儒 李家龙 于盛洋 肖忆楠 赖琛[1,2] 盛立远 黄艺[1,2,3] WU Yuandong;ZHENG Weishuang;LI Yuanju;DU Beining;ZHANG Xingru;LI Jialong;YU Shengyang;XIAO Yinan;LAI Chen;SHENG Liyuan;HUANG Yi(Shenzhen Institute,Peking University,Shenzhen 518057,Guangdong,China;PKU-HKUST ShenZhen-HongKong Institution,Shenzhen 518057,Guangdong,China;School of Environmental Science and Engineering,Peking University,Beijing 100871,China)

机构地区：[1]北京大学深圳研究院,广东深圳518057 [2]深港产学研基地,广东深圳518057 [3]北京大学环境科学与工程学院,北京100871

出　　处：《材料导报》2023年第3期230-238,共9页Materials Reports

基　　金：深圳市中央引导地方科技发展专项资金(2021Szvup001);广东省海洋经济发展(海洋六大产业)专项资金项目(粤自然资合[2020]034号);深圳市基础研究学科布局项目(JCYJ20170815153143221,JCYJ202000109144604020);中国博士后科学基金(2021M690247);深港产学研创新基金(HT-JD-CXY-201902,HT-JD-CXY-201907)。

摘　　要：在意外事故、自然灾害及军事冲突中,人体会受到严重外部创伤,出现大量的不可控出血,极易导致伤员的缺血性休克甚至死亡。因此,伤口的快速止血是提高伤者存活率的关键,快速止血一般需要借助止血材料实现。聚羟基脂肪酸酯(PHAs)是一种天然高分子化合物,具有良好的生物相容性、生物可降解性、可改性等特性,其降解产物还具有促进活体细胞增殖和分化的作用,可加速伤口愈合,是一种极具潜力的止血材料,受到生物医学研发人员的广泛关注。但在应用过程中,PHAs基材料在韧性、抗菌和凝血能力方面仍然存在缺陷。因此,若想开发基于PHAs的止血材料,必须对其韧性、抗菌能力及凝血性能进行改善。本文综述了近年来PHAs基材料在韧性、抗菌能力以及凝血性能等方面的研究进展,可为PHAs基止血材料的研究开发提供参考。PHAs基止血材料具有较高的经济价值,相关研究对严重创伤的救护和新型生物材料的应用推广具有重要意义。During accidents,natural disasters and war,the body of human may suffer serious physical trauma,which will lead uncontrollable massive blood loss.This may further result in ischemic shock and death in the injured.Therefore,fast hemostasis of wound is the key to improve the survival rate of the injured.Fast hemostasis is generally based on using hemostatic materials.Polyhydroxyalkanoates(PHAs),a natural polymer compound,has good biocompatibility,biodegradability and modifying properties.The degradation products of PHAs can also promote the proliferation and differentiation of cells,which can further facilitate healing of wound.Hence PHAs is a good matter of developing hemostatic materials and has attracted extensive attention from biomedical materials researchers.However,PHAs-based materials still have some shortcomings,such as poor toughness,low antibacterial and coagulation performance.Before developing PHAs-based hemostatic materials,the toughness,antibacterial capacity and coagulation performance need to be improved.This review summarizes the research progress of PHAs-based hemostatic materials in recent years,which may provide effective methods and instructions for researching and developing the PHAs-based hemostatic materials.The successful development of PHAs-based hemostatic materials with great socioeconomic value will have significance for emergency of military and sustainable development of mankind.

关 键 词：聚羟基脂肪酸酯 力学性能 止血材料 凝血 抗菌 

分 类 号：R318.08[医药卫生—生物医学工程]