PM_(2.5)暴露影响终止高血压饮食模式与中心性肥胖的相关性  

Correlation between dietary approaches to stop hypertension pattern and central obesity affected by PM_(2.5)exposure

作　　者：张焕文 乔婷婷 陈珍 罗涛 张泽文[1] 王璐[1] 戴江红[1] ZHANG Huanwen;QIAO Tingting;CHEN Zhen;LUO Tao;ZHANG Zewen;WANG Lu;DAI Jianghong(School of Public Health,Xinjiang Medical University,Urumqi,Xinjiang 830017,China;School of Nursing,Xinjiang Medical University,Urumqi,Xinjiang 830017,China)

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830017 [2]新疆医科大学护理学院,新疆乌鲁木齐830017

出　　处：《环境与职业医学》2022年第11期1262-1268,共7页Journal of Environmental and Occupational Medicine

基　　金：国家重点研发计划项目(2017YFC0907203);国家自然科学基金项目(82160640);新疆维吾尔自治区研究生创新项目(XJ2022G182)。

摘　　要：[背景]PM_(2.5)及其组分暴露是否影响终止高血压饮食(DASH)模式与中心性肥胖之间的关系尚缺乏证据。[目的]探讨PM_(2.5)及其组分暴露对DASH模式与中心性肥胖患病相关性的影响。[方法]数据来源于“新疆多民族自然人群队列建设及健康随访研究”乌鲁木齐市人群基线调查。根据8种食物组摄入频率计算DASH评分,推荐摄入的食物组摄入频率由低到高分别为1~5分,而限制摄入的食物组摄入频率由高到低分别为1~5分,总分即为DASH评分,评分越高,研究对象对DASH模式的依从性越好;对应用卫星获得的PM_(2.5)和全球大气化学传输模式(GEOS-Chem)估计的有机碳(OC)、黑炭(BC)、硫酸盐(SO_(4)^(2-))、硝酸盐(NO_(3)^(-))、铵盐(NH_(4)^(+))及扬尘进行暴露评估;以男性腰围≥90 cm或女性腰围≥85 cm定义为中心性肥胖(WS/T428—2013《成人体重判定》)。采用logistic回归模型分析DASH模式、PM_(2.5)及其组分对中心性肥胖的影响,采用分层分析探讨PM_(2.5)及其组分对DASH模式和中心性肥胖关联的影响。[结果]研究共纳入9565名城市居民,年龄(62.30±9.42)岁,中心性肥胖患病率为60.75%。调整混杂因素后,DASH评分Q5组比Q1组中心性肥胖患病可能性降低17.5%(OR=0.825,95%CI:0.720~0.947)。PM_(2.5)及其组分OC、BC、SO_(4)^(2-)、NH_(4)^(+)、扬尘与中心性肥胖患病呈正相关,未见组分NO_(3)^(-)暴露与中心性肥胖有关联。分层分析发现,暴露于低浓度PM_(2.5)及其组分NO_(3)^(-)、NH_(4)^(+)、扬尘的研究对象中,DASH评分Q5组中心性肥胖患病可能性降低,而暴露于高浓度PM_(2.5)及其组分NO_(3)^(-)、NH_(4)^(+)、扬尘的研究对象中,DASH模式对中心性肥胖的保护效应消失。[结论]PM_(2.5)及其组分NO_(3)^(-)、NH_(4)^(+)、扬尘暴露会削弱DASH模式对中心性肥胖的保护效应。[Background]There is a lack of evidence on whether exposure to PM_(2.5)and its constituents would affect the relationship between the dietary approaches to stop hypertension(DASH)and central obesity.[Objective]To investigate the effect of exposure to PM_(2.5)and its constituents on the correlation between the DASH dietary pattern and the prevalence of central obesity.[Methods]The data were obtained from the baseline survey of the"Xinjiang Multi-Ethnic Natural Population Cohort Construction and Health Follow-Up Study"in Urumqi.A DASH score was calculated according to intake frequency of 8 food groups,and summed from intake frequency of recommended food groups scored from 1 to 5 from low to high,and intake frequency of restricted food groups scored from 1 to 5 from high to low.A higher DASH score indicates better compliance with the DASH dietary pattern.We estimated exposure using satellite-derived PM_(2.5)and a chemical transport model(GEOS-Chem)for its constituents,including organic carbon(OC),black carbon(BC),sulfate(SO_(4)^(2-)),nitrate(NO_(3)^(-)),ammonium(NH_(4)^(+)),and soil dust.Central obesity was defined by waist circumference:≥90 cm for men or≥85 cm for women according to Criteria of weight for adults(WS/T 428—2013).A logistic regression model was used to analyze the effects of the DASH dietary pattern as well as PM_(2.5)and its constituents on central obesity,and a stratified analysis was used to explore the effects of PM_(2.5)and its constituents on the association between the DASH dietary pattern and central obesity.[Results]The study included 9565 urban residents,aged(62.30±9.42)years,with a central obesity prevalence rate of 60.75%.After adjusting for selected confounders,the DASH score Q5 group had a 17.5%lower risk of central obesity than the Q1 group(OR=0.825,95%CI:0.720-0.947).PM_(2.5)and its constituents OC,BC,SO_(4)^(2-),NH_(4)^(+),and soil dust were positively associated with the prevalence of central obesity,but no association was observed between constituent NO_(3)^(-)exposure and ce

关 键 词：终止高血压饮食 PM_(2.5) 中心性肥胖 细颗粒物组分 

分 类 号：R12[医药卫生—环境卫生学]