Electrospun N-halamine/ZnO-based platform eradicates bacteria through multimodal antimicrobial mechanism of action  

作　　者：Hui-Hui Qu Cong Wang Yi-Xuan Guo Zi-Ying Zhao Long Qiao Jie-Bing Yang Hai-Xia Wu Quan-Shun Li Alideertu Dong 

机构地区：[1]College of Chemistry and Chemical Engineering,Engineering Research Center of Dairy Quality and Safety Control Technology,Ministry of Education,Inner Mongolia University,Hohhot,010021,China [2]Center of Experimental Instrument,School of Food Science and Technology,Dalian Polytechnic University,Dalian,116034,China [3]Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education,School of Life Sciences,Jilin University,Changchun,130012,China

出　　处：《Rare Metals》2023年第1期222-233,共12页稀有金属（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.21304044,51663019 and 22062017);the Natural Science Foundation of Inner Mongolia Autonomous Region(Nos.2015MS0520 and 2019JQ03);the State Key Laboratory of Medicinal Chemical Biology(Nos.201603006 and 2018051);the State Key Laboratory of Polymer Physics and Chemistry(No.2018-08);the Program of HigherLevel Talents of Inner Mongolia University(No.30105-125136)。

摘　　要：The emergence and prevalence of antibiotic-resistant bacteria demands powerful antibacterial tactics to combat infectious microorganisms.Enhanced combinational therapy based on synergistic hybrid antibacterial materials is a promising approach to realize effective sterilization through the rational integration of distinct bactericides into one compact platform.In this work,we constructed a microfiber-based antibacterial platform(PAM-Cl/ZnO MFs)by electrospinning N-halamine polymers(PAM-Cl)loaded with zinc oxide(ZnO)nanoparticles.The as-designed PAM-Cl/ZnO MFs inherited the intrinsic antibacterial effects of both PAM-Cl microfibers(PAM-Cl MFs)and ZnO microfibers(ZnO MFs),and the material exhibited enhanced synergistic antibacterial performance against Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli)in vitro.The bactericidal effect was multimodal and included contact killing based on the N-Cl bond of N-halamine,multiple-release killing,such as reactive oxygen species(ROS)under light irritation,and Zn^(2+)and Cl^(+)acting as antibacterial agents.Importantly,PAM-Cl/Zno MFs worked on inactivate bacteria even under harsh temperatures and atmospheric conditions.Additionally,PAM-Cl/ZnO MFs exhibited good biocompatibility and performed outstanding acceleration of wound healing with in vivo mouse skin defect models using S.aureus.This work advances the design of antibacterial hybrid materials with the potency to eradicate bacteria in biological systems in multiple settings through the superiority of multimodal synergistic therapy.

关 键 词：N-HALAMINE ZnO nanoparticles ELECTROSPINNING Synergistic antibacterial therapy Various scenarios 

分 类 号：TB3[一般工业技术—材料科学与工程]