肽基多孔材料及其应用  

Peptide-based porous materials and their applications

作　　者：王跃飞 闵继伟 魏豪 刘佳羽 梁耀宇 苏荣欣 张弓 张伟 王跃飞 齐崴 Yuefei Wang;Jiwei Min;Hao Wei;Jiayu Liu;Yaoyu Liang;Rongxin Su;Gong Zhang;Wei Zhang;Yuefei Wang;Wei Qi(State Key Laboratory of Chemical Engineering,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;State Key Laboratory of Component-based Chinese Medicine,Haihe Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Membrane Science and Desalination Technology,Tianjin University,Tianjin 300072,China;Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function,Soochow University,Suzhou 215123,China;State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou Industrial Park,Suzhou 215123,China;Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin 300072,China)

机构地区：[1]State Key Laboratory of Chemical Engineering,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China [2]State Key Laboratory of Component-based Chinese Medicine,Haihe Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [3]Tianjin Key Laboratory of Membrane Science and Desalination Technology,Tianjin University,Tianjin 300072,China [4]Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function,Soochow University,Suzhou 215123,China [5]State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou Industrial Park,Suzhou 215123,China [6]Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin 300072,China

出　　处：《Science China Materials》2023年第2期470-484,共15页中国科学（材料科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(22278306,22278314,21621004 and 22078239);the State Key Laboratory of Chemical Engineering(SKL-ChE-21T03)。

摘　　要：多肽自组装形成的多孔结构是新一代多孔材料,在催化、传感、分离和药物递送等领域具有很好的应用前景.肽基多孔材料的孔内充满氨基酸侧链,因此可以通过合理设计或修改肽序列来调节其孔径大小和性能.功能基团和金属离子的引入进一步扩展了多肽基多孔材料的结构与性能.在这篇综述中,我们讨论了肽基多孔材料的设计、合成、组装及其性能,并综述了近年来其在不同领域的应用.The porous structure formed by the self-assembly of peptides is a new generation of porous materials with potential applications in the fields of catalysis,sensing,separation,and drug delivery.The pores of the material are filled with amino acid side chains,so the pore size and properties of the peptide-based porous material can be adjusted by rational design or modification of the peptide sequences.The introduction of functional moieties and metal ions has expanded the range of peptide-based porous materials.This review covers the design,synthesis,self-assembly,and properties of peptide-based porous materials,and summarizes their applications in different fields in recent years.

关 键 词：多孔材料 药物递送 氨基酸侧链 自组装 多孔结构 功能基团 金属离子 孔径大小 

分 类 号：TB332[一般工业技术—材料科学与工程]