震颤型与强直型帕金森病静息态脑功能度中心性的差异  

Difference of resting brain function degree centrality between tremor and akinetic-rigid dominant Parkinson disease

作　　者：宋宸蝶 周繁 廖海燕[1] 沈琴[1] 王敏[1] 蔡赛男[1] 谭长连[1] SONG Chendie;ZHOU Fan;LIAO Haiyan;SHEN Qin;WANG Min;CAI Sainan;TAN Changlian(Department of Radiology,the Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院放射科,湖南长沙410011

出　　处：《中国医学影像技术》2023年第2期166-170,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家重点研发计划项目(2022YFC2009900);湖南省自然科学基金项目(2022JJ30818);湖南省临床医疗技术创新引导项目(2021SK53502);长沙市自然科学基金项目(kq2202416)。

摘　　要：目的观察震颤(TD)型与强直(ARD)型帕金森病(PD)静息态脑功能度中心性(DC)差异。方法采集51例TD(TD组)型、39例ARD(ARD组)型PD患者及56名健康对照者(HC,HC组)头部静息态功能MRI数据,比较组间全脑DC值的差异。结果相比HC组,TD组及ARD组双侧小脑DC值升高;TD组左侧壳核和左侧中央旁小叶DC值降低,ARD组左侧前扣带回和右侧辅助运动区DC值降低。相比ARD组,TD组左侧前扣带回和右侧辅助运动区DC值升高,双侧小脑DC值减低。结论TD型与ARD型PD患者双侧小脑、左侧前扣带回及右侧辅助运动区DC存在差异。Objective To observe the difference of degree centrality(DC)between tremor(TD)and akinetic-rigid dominant(ARD)Parkinson disease(PD)patients with resting-state brain functional MRI.Methods Head resting-state functional MRI data were collected from 51 TD(TD group),39 ARD(ARD group)PD patients and 56 healthy controls(HC group),and the differences of the whole brain DC values were compared among 3 groups.Results Compared with HC group,DC values of bilateral cerebellum increased in both TD and ARD groups,of the left putamen and paracentral lobule decreased in TD group,while decreased in the left anterior cingulate gyrus and right supplementary motor area in ARD group.Compared with ARD group,DC values decreased in bilateral cerebellar hemispheres but increased in the left anterior cingulate gyrus and right supplementary motor area in TD group.Conclusion TD and ARD PD patients had different DC in bilateral cerebellum,left anterior cingulate gyrus and right supplementary motor area.

关 键 词：帕金森病 磁共振成像 静息态 度中心性 

分 类 号：R714.14[医药卫生—妇产科学] R445.2[医药卫生—临床医学]