乙酰基六肽-8脂质体的功效性能及安全性研究  

Study on the efficacy and safety of the acetyl hexapeptide-8 liposome

作　　者：邓燕柠 卢利平 周心慧 郑华生 程建华 DENG Yan-ning;LU Li-ping;ZHOU Xin-hui;ZHENG Hua-sheng;CHENG Jian-hua(South China Institute of Collaboration Innovation,Dongguan,Guangdong 523000,China;Guangdong Gasia Commodity Technology Co.,Ltd.,Qingyuan,Guangdong 511500,China;Guangzhou Chaohui Biotek Co.,Ltd.,Guangzhou,Guangdong 510700,China;Dongguan Chuawei Biotechnologies Co.,Ltd.,Dongguan,Guangdong 523808,China)

机构地区：[1]华南协同创新研究院,广东东莞523000 [2]广东加茜亚日用品科技有限公司,广东清远511500 [3]广州潮徽生物科技有限公司,广东广州510700 [4]东莞华工创为生物科技有限公司,广东东莞523808

出　　处：《日用化学品科学》2023年第2期17-23,共7页Detergent & Cosmetics

摘　　要：以乙酰基六肽-8脂质体为研究对象,通过体外方法与体内方法对乙酰基六肽-8脂质体的耐酶解能力、缓释能力、皮肤渗透能力、人体使用效果及安全性进行研究。结果显示,在体外皮肤提取液模拟的酶环境中,乙酰基六肽-8脂质体具有耐酶降解的能力,优于未经脂质体包裹的游离态乙酰基六肽-8。在生理盐水体外环境中,乙酰基六肽-8脂质体具有缓释能力,优于未经脂质体包裹的乙酰基六肽-8。通过对体外动物皮肤切片的观察,乙酰基六肽-8脂质体的皮肤渗透能力优于未经脂质体包裹的乙酰基六肽-8。在同等肽含量条件下,乙酰基六肽-8脂质体乳液淡化皱纹、提升皮肤角质层水分含量的效果明显优于乙酰基六肽-8乳液。乙酰基六肽-8脂质体安全性高,可作为抗皱保湿的活性原料用于皮肤护理领域。Taking acetyl hexapeptide-8 liposome as the research object,the enzymatic resistance,sustained release ability,skin penetration ability,the efficacy on human skin and the safety thereof,were studied by in vitro and in vivo methods.The results showed that,in an in vitro enzymatic environment simulated by skin extracts,acetyl hexapeptide-8 liposome was resistant to the enzymatic degradation,which was better than acetyl hexapeptide-8.In the in vitro environment of normal saline,acetyl hexapeptide-8 liposome had sustained release ability,which was better than acetyl hexapeptide-8.According to the observation of in vitro animal skin,the skin penetration of acetyl hexapeptide-8 liposome was better than that of acetyl hexapeptide-8.The effects of acetyl hexapeptide-8 liposome emulsion in anti-wrinkling and increasing the water content of stratum corneum were significantly better than that of the acetyl hexapeptide-8 emulsion with the same peptide content.Acetyl hexapeptide-8 liposome was safe,and it could be an active ingredient for anti-wrinkle and moisturizing skin care products.

关 键 词：乙酰基六肽-8 脂质体 药代动力学 渗透性 抗皱 

分 类 号：TQ658[化学工程—精细化工]