空间接近二酰胺的多米诺类型反应及其在有机合成中的应用  

Dominoes Type Reaction of Spatially Close Diamides and Their Applications in Organic Synthesis

作　　者：张佳玲 吴源源 张曼 陶正煜 田勇攀 张千峰 童碧海 何谷峰[2] 孔辉 ZHANG Jialing;WU Yuanyuan;ZHANG Man;TAO Zhengyu;TIAN Yongpan;ZHANG Qianfeng;TONG Bihai;HE Gufeng;KONG Hui(Key Laboratory of Metallurgical Emission Reduction&Resources Recycling,Ministry of Education,Institute of Molecular Engineering and Applied Chemistry,School of Metallurgy Engineering,Anhui University of Technology,Maanshan 243002,China;Department of Electronic Engineering,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]安徽工业大学冶金工程学院,分子工程与应用化学研究所,冶金减排与资源循环利用教育部重点实验室,马鞍山243002 [2]上海交通大学电子工程系,上海200240

出　　处：《高等学校化学学报》2023年第2期38-46,共9页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21572001,61975117);安徽省专项支持计划项目(批准号:T000609);皖江学者特聘教授项目和安徽省教育厅科研项目(批准号:YJS20210332)资助.

摘　　要：发现了空间接近的双温勒伯(Weinreb)酰胺与格氏试剂在温和条件下的单取代反应,该反应普适性强、操作简便且产率高,反应存在动力学控制和热力学控制2种产物.机理分析表明,该反应发生了分子内亲核取代反应,并生成了稳定的单取代中间体,从而避免了双取代反应的发生.通过该反应制备了一系列4-取代酞嗪酮类化合物,合成了基于酞嗪基团的纯红光三环金属化铱(Ⅲ)配合物,采用该配合物制备的有机电致发光器件表现出高效率[最大外部量子效率(EQE_(max))=10.3%]和低浓度猝灭性能.A monoaddition reaction of spatially close diamides and Grignard reagents under mild conditions was found.In some case,kinetic-controlled products and thermodynamic-controlled products were obtained at the same time.The key step involved an intramolecular nucleophilic reaction.4-Substituted phthalazinones were conveniently synthesized by this method.Pure red-light-emitting tris-cyclometalated iridium(Ⅲ)complex based on phthalazine building blocks that exhibit high efficiency[maximum external quantum efficiency(EQE_(max))=10.3%]had also been synthesized.

关 键 词：酞嗪酮 双温勒伯酰胺 格氏试剂 铱(Ⅲ)配合物 有机发光二极管 

分 类 号：O621.25[理学—有机化学]