不同生活方式指数对青中年男性人群血尿酸水平的影响  

Impact of different lifestyle indexes on serum uric acid levels in young and middle-aged men

作　　者：李红卫 沈振海 贾冰[3] 张彤 李绍雷 张萍 袁芳岑 陆昀 Li Hongwei;Shen Zhenhai;Jia Bing;Zhang Tong;Li Shaolei;Zhang Ping;Yuan Fangcen;Lu Yun(Department of Rehabilitation,the Affiliated Wuxi People′s Hospital of Nanjing Medical University,Wuxi 214023,China;Department of Cardiovascular Medicine,Jiangsu Provincial People′s Hospital Group Taihu Sanatorium of Jiangsu Province,Wuxi 214086,China;Department of Endocrine,Affiliated Hospital of Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China)

机构地区：[1]南京医科大学附属无锡人民医院康复医学科,无锡214023 [2]江苏省人民医院集团江苏省太湖疗养院心内科,无锡214086 [3]江苏省原子医学研究所附属江原医院内分泌科,无锡214063

出　　处：《中华内分泌代谢杂志》2022年第12期1034-1039,共6页Chinese Journal of Endocrinology and Metabolism

基　　金：江苏省医学重点学科(共建)项目(IDXKC2016011);江苏省干部保健科研课题(BJ21032)。

摘　　要：目的探讨生活方式指数(LSI)对青中年男性人群血尿酸水平的影响。方法采用横断面研究,抽取2020年3月至2021年6月于江苏省太湖疗养院体检的青中年男性8067名,年龄(46.46±8.81)岁。根据年龄将受检者分为青年男性组(18~44岁)3269名和中年男性组(45~60岁)4798名。收集受检者身高、体重、体重指数、饮酒、吸烟、饮食、运动、空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血尿酸等资料。结果纳入人群血尿酸水平为(376.80±74.43)μmol/L,高尿酸血症患病率为25.7%。青年男性组血尿酸水平高于中年男性组[(381.86±74.32)μmol/L对(373.34±74.32)μmol/L,P<0.001],青年男性组高尿酸血症患病率高于中年男性组(27.4%对24.5%),差异有统计学意义(P<0.001)。随着LSI得分增加,青中年男性血尿酸水平及高尿酸血症患病率均呈降低趋势(P<0.01)。Logistic回归分析显示,调整年龄、空腹血糖、总胆固醇、三酰甘油、HDL-C、LDL-C、高血压和糖尿病后,LSI是青中年男性血尿酸水平的独立影响因素;LSI每增加1分,青年和中年人群高尿酸血症患病风险均降低(OR分别为0.83和0.84,P<0.01);青年男性组人群运动和体重指数与高尿酸血症独立相关(OR分别为0.83和0.54,P<0.05),中年男性组人群运动、体重指数和饮酒与高尿酸血症独立相关(OR分别为0.85,0.51和0.65,P<0.05)。结论LSI是青中年男性高尿酸血症的独立影响因素,健康的生活方式对青中年男性血尿酸水平有保护作用。Objective To investigate the impact of lifestyle index(LSI)on serum uric acid levels in young and middle-aged men.Methods This was a cross sectional study.A total of 8067 subjects underwent check-up in Taihu Sanatorium of Jiangsu Province from March 2020 to June 2021 were enrolled,average age were(46.46±8.81)years.According to age,subjects were divided into young male group(18-44 years old,n=3269)and middle-aged male group(45-60 years old,n=4798).Height,weight,body mass index,alcohol drinking,smoking,diet,exercise,fasting blood glucose,total cholesterol,triglycerides,high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),serum uric acid and other data in all cases were measured and recorded.Results The serum uric acid level in allsubjects was(376.80±74.43)μmol/L and the prevalence of hyperuricemia was 25.7%.The serum uric acid level in the young male group was higher than that in the middle-aged male group[(381.86±74.32)μmol/L vs(373.34±74.32)μmol/L,P<0.001].The prevalence of hyperuricemia in the young male group was higher than that in the middle-aged male group(27.4%vs 24.5%),and the difference was statistically significant(P<0.001).With the improvement of LSI scores,the serum uric acid levels in young and middle-aged men showed a decreasing trend(P<0.01).Logistic regression analysis showed that after adjusting for age,fasting blood glucose,total cholesterol,triglyceride,HDL-C,LDL-C,hypertension,and diabetes,LSI was an independent factor for serum uric acid levels in young and middle-aged men.The risk of hyperuricemia in young and middle-aged male decreased(OR 0.83 and 0.84,respectively,P<0.01)for every 1-point increase in LSI.Exercise and body mass index were independently associated with hyperuricemia in the young male group(OR 0.83 and 0.54,respectively,P<0.05).Exercise,body mass index,and alcohol drinking were independently associated with hyperuricemia in the middle-aged male group(OR 0.85,0.51 and 0.65,respectively,P<0.05).Conclusion LSI is an independent factor asso

关 键 词：生活方式指数 体重指数 血尿酸 青中年男性 

分 类 号：R589.7[医药卫生—内分泌]