减重后体重反弹的机制探讨  

Mechanisms of weight regain after weight loss

作　　者：邹雨瑶 洪洁[1] Zou Yuyao;Hong Jie(National Clinical Research Center for Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Department of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病研究所,国家代谢性疾病临床医学研究中心,上海200025

出　　处：《中华内分泌代谢杂志》2022年第12期1098-1102,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(81870582,82070863);上海市优秀学科带头人计划(19XD1403200)。

摘　　要：肥胖是一种极易复发的慢性非传染性疾病。尽管目前可通过许多方式对肥胖进行有效干预,体重反弹的现象仍常有发生。体重反弹现象涉及许多潜在的代偿机制,包括脂肪细胞、能量代谢、肠道激素、中枢调控、肠道菌群等多方面的改变,这些机制可能通过肠-脑轴产生交互作用,最终影响减重的长期预后。本文总结了减重后体重反弹的可能机制,以期为预防体重反弹的相关研究提供一定线索。Obesity is a chronic noncommunicable disease with a high tendency to rebound.Although successful weight loss can be achieved with multiple means,weight regain is common.Various compensatory mechanisms underlie such phenomenon,including alterations in adipocytes,energy metabolism,gut hormones,central appetite modulation,and gut microbiome.These changes may interact with each other through gut-brain axis,and influence long-term weight maintenance.The present review focuses on potential mechanisms of weight regain to shed light on further research in this field.

关 键 词：肥胖 体重减轻 体重反弹 

分 类 号：R589.2[医药卫生—内分泌]