双相情感障碍不同临床相患者血清系统性炎症因子与肠道菌群差异性的比较研究  

A comparison study on serum systemic inflammatory factors and intestinal flora in patients with different clinical phases of bipolar disorder

作　　者：朱莉清 张鹏[2] 徐洁颖 ZHULi-qing;ZHANG Peng;XU Jie-ying(Zhejiang Chinese Medical University,Hangzhou,Zhejiang 311202,China;不详)

机构地区：[1]浙江中医药大学,浙江杭州311202 [2]杭州师范大学附属萧山医院

出　　处：《中国卫生检验杂志》2022年第24期3011-3014,3019,共5页Chinese Journal of Health Laboratory Technology

基　　金：杭州萧山区科技计划项目(2018321)。

摘　　要：目的 探讨双相情感障碍不同临床相患者血清系统性炎症因子与肠道菌群差异性的相关研究。方法 比较双相情感障碍患者躁狂发作期组、抑郁发作期组及对照组3组肠道菌群分布情况,及炎症因子、肝肾功能、甲状腺功能、激素水平,并采用Pearson相关分析法分析不同临床相肠道菌群与炎症因子的相关性。结果 各组间一般临床资料及肝肾功能、激素水平差异无统计学意义(P>0.05);躁狂发作期组炎症因子结果明显高于其余2组(P<0.05)。肠道菌群Alpha多样性比较:患者2组Simpson指数明显高于对照组(P<0.05);相反患者2组Chao指数与Ace指数明显低于对照组(P<0.05);患者2组肠道双歧杆菌种、拟杆菌种相对丰度明显低于对照组(P<0.05);躁狂发作期组大肠杆菌种相对丰度明显高于B、C2组;抑郁发作期组在粪便厚壁菌种相对丰度明显高于其余2组;躁狂发作期组与抑郁发作期组患者肠道菌群与细胞因子均无相关性,差异无统计学意义(P>0.05)。结论 双相情感障碍不同临床相患者肠道菌群多样性及相对丰度均存在差异,肠道菌群紊乱及炎症因子异常可能参与了双相情感障碍患者的发病。Objective This study aims to investigate the correlation between serum systemic inflammatory factors and intestinal flora in patients with different clinical phases of bipolar disorder(BD). Methods The distribution of intestinal flora, inflammatory factors, liver and kidney functions, thyroid function and hormone levels were compared in control group and the BD patients of manic attack group and the depressive attack group. Results There was no statistical significance on the difference in general clinical data, liver and kidney functions and hormone level among the groups(P>0.05). The results of inflammatory factors in manic attack group were significantly higher than those in depressive attack group and control group. Comparison of Alpha diversity of intestinal flora showed that Simpson index in manic attack group and depressive attack group were significantly higher than that in control group(P<0.05). On the contrary, the Chao index and Ace index in manic attack group and depressive attack group were significantly lower than those in control group(P<0.05). The relative abundance of Bifidobacterium species and Bacteroides species in depressive attack group was significantly lower than that in control group(P<0.05). The relative abundance of E. coli species in manic attack group was significantly higher than that in depressive attack group and control group. The relative abundance of thick wall bacteria in feces in depressive attack group was significantly higher than that in manic attack group and control group. There was no correlation between intestinal flora and cytokines in depressive attack group, with the differences not statistically significant(P>0.05). Conclusion There are differences in the diversity and relative abundance of intestinal flora in patients with different clinical phases of bipolar disorder. Intestinal flora disorder and abnormal inflammatory factors may be involved in the pathogenesis of bipolar disorder.

关 键 词：双相情感障碍 肠道菌群 躁狂发作 抑郁发作 

分 类 号：R446[医药卫生—诊断学]