托尼萘酸片+胆宁片治疗非酒精性脂肪肝的临床效果及对患者身体质量指数、肝功能及血脂指标的影响  

Clinical effect of tolynicate and naphthylacetic acid tablets+danning tablets in the treatment of non-alcoholic fatty liver disease and its influences on body mass index,liver function and blood lipid indexes of patients

作　　者：李均[1] 张光只 LI Jun;ZHANG Guangzhi(Comprehensive Outpatient Department,Luoyang Institute of Electro-Optical Equipment,Aviation Industry Corporation of China,Luoyang 471000,China)

机构地区：[1]中国航空工业集团公司洛阳电光设备研究所综合门诊部,河南洛阳471000

出　　处：《临床医学研究与实践》2023年第6期39-42,共4页Clinical Research and Practice

摘　　要：目的分析托尼萘酸片+胆宁片治疗非酒精性脂肪肝的临床效果及对患者身体质量指数、肝功能及血脂指标的影响。方法选取我院2021年3月至2022年3月收治的98例非酒精性脂肪肝患者作为研究对象,使用随机数字表法将其分为常规组(49例,胆宁片)和观察组(49例,托尼萘酸片+胆宁片)。比较两组的治疗效果。结果观察组的治疗总有效率为97.96%,明显高于常规组的85.71%,差异具有统计学意义(P<0.05)。治疗后,观察组的身体质量指数和丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、总胆汁酸(TBA)水平均明显低于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显低于常规组,高密度脂蛋白(HDL)水平明显高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的空腹胰岛素(FINS)水平、胰岛素抵抗指数(HOMA-IR)明显低于常规组,胰岛素分泌指数(HOMA-β)、胰岛素敏感指数(HOMA-ISI)明显高于常规组,差异具有统计学意义(P<0.05)。两组治疗期间的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论托尼萘酸片+胆宁片治疗非酒精性脂肪肝的临床效果显著,可促进患者肝功能恢复,降低血脂,调节糖脂代谢功能,且安全性较高。Objective To analyze the clinical effect of tolynicate and naphthylacetic acid tablets+danning tablets in the treatment of non-alcoholic fatty liver disease and its influences on body mass index,liver function and blood lipid indexes of patients.Methods A total of 98 patients with non-alcoholic fatty liver disease admitted in our hospital from March 2021to March 2022 were selected as the research objects and divided into conventional group(49 cases,danning tablets)and observation group(49 cases,tolynicate and naphthylacetic acid tablets+danning tablets)by random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 97.96%,which was significantly higher than 85.71%in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the body mass index and the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and total bile acids(TBA)in the observation group were significantly lower than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the levels of total cholesterol(TC),triglycerides(TG)and low-density lipoproteincholesterol(LDL-C)in the observation group were significantly lower than those in the conventional group,the level of high density lipoprotein(HDL)was significantly higher than that in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the fasting insulin(FINS)level and homeostasis model assessment-insulin resistance(HOMA-IR)in the observation group were significantly lower than those in the conventional group,the homeostasis model assessment-β(HOMA-β)and homeostasis model assessment-insulin sensitivity index(HOMA-ISI)were significantly higher than those in the conventional group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the t

关 键 词：非酒精性脂肪肝 托尼萘酸片 胆宁片 肝功能 用药安全 

分 类 号：R975[医药卫生—药品]