头孢他啶与头孢替安治疗小儿肠炎的临床效果比较  

Comparison of clinical effects of ceftazidime and cefotiam in the treatment of infantile enteritis

作　　者：曹雯 孙蕾 陈玺[3] CAO Wen;SUN Lei;CHEN Xi(Xi'an Chengbei Hospital,Xi'an 710021;the Hospital of Qishan County,Baoji 722400;the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]西安城北医院,陕西西安710021 [2]岐山县医院,陕西宝鸡722400 [3]西安交通大学第二附属医院,陕西西安710004

出　　处：《临床医学研究与实践》2023年第6期77-80,共4页Clinical Research and Practice

摘　　要：目的比较头孢他啶与头孢替安治疗小儿肠炎的临床效果。方法选取2019年1月至2020年12月我院收治的100例肠炎患儿作为研究对象,根据临床用药差异将其分为头孢替安组(n=50,头孢替安治疗)与头孢他啶组(n=50,头孢他啶治疗)。比较两组的临床疗效、炎症因子水平、免疫指标、临床指标况及药副反应发生情况。结果头孢他啶组的治疗总有效率为96.00%,显著高于头孢替安组的82.00%,差异具有统计学意义(P<0.05)。治疗后,头孢他啶组的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-1β(IL-1β)、C反应蛋白(CRP)及降钙素原(PCT)水平均显著低于头孢替安组,差异具有统计学意义(P<0.05)。治疗后,头孢他啶组的白细胞分化抗原4阳性(CD4^(+))与白细胞分化抗原4阳性/白细胞分化抗原8阳性(CD4^(+)/CD8^(+))均显著高于头孢替安组,白细胞分化抗原8阳性(CD8^(+))显著低于头孢替安组,差异具有统计学意义(P<0.05)。头孢他啶组的大便恢复正常时间、腹泻持续时间短于头孢替安组,每日排便次数少于头孢替安组,差异具有统计学意义(P<0.05)。头孢他啶组的药副反应总发生率为2.00%,显著低于头孢替安组的14.00%,差异具有统计学意义(P<0.05)。结论头孢他啶治疗小儿肠炎较头孢替安治疗的效果更佳,前者可快速改善患儿的临床症状、炎症反应及免疫功能,且药副反应发生率更低,临床应用价值较高。Objective To compare the clinical effects of ceftazidime and cefotiam in the treatment of infantile enteritis.Methods A total of 100 children with enteritis admitted in our hospital from January 2019 to December 2020 were selected as the research objects.According to the difference of clinical medication,the children were divided into cefotiam group(n=50,cefotiam treatment)and ceftazidime group(n=50,ceftazidime treatment).The clinical efficacy,inflammatory factors levels,immune indexes,clinical indexes and occurrence of adverse drug reactions were compared between the two groups.Results The total effective rate of treatment in the ceftazidime group was 96.00%,which was significantly higher than82.00%in the cefotiam group,and the difference was statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),interleukin-1β(IL-1β),C-reactive protein(CRP)and procalcitonin(PCT)in the ceftazidime group were significantly lower than those in the cefotiam group,and the differences were statistically significant(P<0.05).After treatment,the cluster of differentiation 4 positive(CD4^(+))and cluster of differentiation 4 positive/cluster of differentiation 8 positive(CD4^(+)/CD8^(+))in the ceftazidime group were significantly higher than those in the cefotiam group,the cluster of differentiation 8 positive(CD8^(+))was significantly lower than that in the cefotiam group,and the differences were statistically significant(P<0.05).The time of stool returning to normal,the duration of diarrhea in the ceftazidime group were shorter than those in the cefotiam group,the number of daily defecation was less than that in the cefotiam group,and the differences were statistically significant(P<0.05).The total incidence of adverse drug reactions in the ceftazidime group was 2.00%,which was significantly lower than 14.00%in the cefotiam group,and the difference was statistically significant(P<0.05).Conclusion Ceftazidime is more effective than cefotiam in the treatme

关 键 词：小儿肠炎 头孢他啶 头孢替安 

分 类 号：R720.5[医药卫生—儿科]