IL-37与过敏性疾病的研究进展  

Research progress of IL-37 and allergic diseases

作　　者：高雯雯 郅莉莉 吴福玲[3] 马立吉 Gao Wenwen;Zhi Lili;Wu Fuling;Ma Liji(First Clinical Medical College,Binzhou Medical University,Binzhou 256600,China;Department of Allergy,Shandong Qianfo Mountain Hospital,Jinan 250000,China;Department of Pediatrics,Binzhou Medical University Hospital,Binzhou 256600,China;Department of Pediatrics,Zibo Central Hospital,Zibo 255000,China)

机构地区：[1]滨州医学院第一临床医学院,滨州256600 [2]山东省千佛山医院变态反应科,济南250000 [3]滨州医学院附属医院儿科,滨州256600 [4]淄博市中心医院儿科,淄博255000

出　　处：《国际医药卫生导报》2023年第4期461-464,共4页International Medicine and Health Guidance News

摘　　要：过敏性疾病是机体免疫系统对外来变应原产生的超敏反应性疾病,目前糖皮质激素作为治疗过敏性疾病的一线用药,其临床应用与治疗效果具有一定的局限性及不良反应。白细胞介素-37(interleukin-37,IL-37)作为天然的先天性和适应性免疫抑制剂,具有双重抗炎功能,可同时抑制炎症因子和激活抗炎因子的表达。研究表明,IL-37可通过多种作用机制及通路来维持过敏性疾病中免疫系统的动态平衡。因此,本文将基于分析IL-37的本身特性,对其在儿童常见的过敏性疾病中的作用机制作一综述,旨在为进一步研究和临床诊疗提供依据。Allergic diseases are diseases with hypersensitive reactions of the body's immune system to foreign allergens.Glucocorticoids are currently used as the first-line drugs in the treatment of allergic diseases,but their clinical application and therapeutic effect have certain limitations and by-effects.As a natural innate and adaptive immunosuppressive agent,interleukin-37(IL-37)has dual anti-inflammatory functions.It can inhibit the expression of inflammatory factors and activate anti-inflammatory factors at the same time.Studies have shown that IL-37 can maintain the homeostasis of the immune system in patients with allergic diseases through a variety of mechanisms and pathways.This article reviews the mechanism of IL-37 in children's common allergic diseases based on the analysis of its own characteristics,so as to provide a basis for further research and clinical diagnosis and treatment.

关 键 词：白细胞介素-37 过敏性哮喘 变应性鼻炎 特应性皮炎 

分 类 号：R593.1[医药卫生—内科学]