强骨饮治疗膝骨关节炎临床疗效及对血清炎症因子的影响  

Clinical efficacy of Strong-bone Decoction in the treatment of knee osteoarthritis and its effect on serum inflammatory factors

作　　者：崔龙慷 李学飞 沈高波 张兵兵 曾晗冰 毛应德龙 史晓林 吴连国 CUI Longkang;LI Xuefei;SHEN Gaobo;ZHANG Bingbing;ZENG Hanbing;MAO Ying Delong;SHI Xiaolin;WU Lianguo(The Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005;Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学附属第二医院,浙江杭州310005 [2]浙江中医药大学第二临床医学院,浙江杭州310053

出　　处：《中国骨质疏松杂志》2023年第1期41-45,共5页Chinese Journal of Osteoporosis

基　　金：浙江省中医药优秀青年人才基金项目(2021ZQ046);浙江省中医药现代化专项(2021ZX009);浙江省中医药科技计划重点研究项目(2019ZZ012);国家中医临床研究基地支撑学科建设计划(2020-JDXK-ZC01);浙江省“十三五”中医药重点专科建设项目(外科-运动创伤科)(浙卫办中医[2019]1号);浙江省中医药优秀青年人才基金项目(2021ZQ47);浙江省中医药科技项目(2022ZB160)。

摘　　要：目的探讨强骨饮治疗膝骨关节炎(knee osteoarthritis,KOA)的临床疗效及其对血清炎症因子的影响。方法将72例KOA患者随机分为对照组和研究组,每组各36例。对照组予以口服塞来昔布胶囊2周、盐酸氨基葡萄糖片12周及阿仑膦酸钠12周治疗,研究组在对照组治疗基础上口服强骨饮12周。治疗12周后观察临床疗效,比较两组治疗前后中医证侯评分、VAS评分、WOMAC评分及SF-36评分,同时采用酶联免疫吸附测定(ELISA)方法检测两组治疗前后血清TNF-α、IL-1β和IL-6的表达水平。结果研究组总有效率(88.89%,32/36)显著高于对照组(69.44%,25/36)(P<0.05)。治疗后两组中医证候评分、WOMAC评分、VAS评分均显著降低(P<0.05),且研究组显著低于对照组(P<0.05);治疗后两组SF-36评分均显著增高(P<0.05),且研究组显著高于对照组(P<0.05);治疗后两组血清TNF-α、IL-1β和IL-6表达水平均显著降低(P<0.05),且研究组显著低于对照组(P<0.05)。结论强骨饮治疗KOA具有较好的临床疗效,并且能够降低患者血清炎症因子水平。Objective To observe the clinical efficacy of Strong-bone Decoction on patients with knee osteoarthritis(KOA)and its effect on the expression of serum inflammatory factors.Methods Patients with KOA were randomly divided into control group(Celebrex for 2 weeks and glucosamine hydrochloride tablets for 12 weeks and alendronate sodium for 12 weeks)and observation group(Celebrex for 2 weeks and glucosamine hydrochloride tablets for 12 weeks and alendronate sodium for 12 weeks,combined with Strong-bone Decoction),with 36 cases in each group.After 12 weeks of treatment,the TCM symptom score,the WOMAC index,the VAS,and the SF-36 score were observed.The serum levels of IL-1β,IL-6,and TNF-αwere detected with ELISA.Results The 88.89%(32/36)total effective rate in the observation group was significantly higher than the 69.44%(25/36)total effective rate in the control group(P<0.05).The TCM symptom score,the WOMAC score,and the VAS in both groups decreased significantly after the treatment(P<0.05).The observation group had lower TCM symptom score,WOMAC score,and VAS than those in the control group,and the differences were statistically significant(P<0.05).The SF-36 score in both groups increased significantly after the treatment(P<0.05).The observation group had higher SF-36 score than the control group,and the difference was statistically significant(P<0.05).Furthermore,the expression levels of serum inflammatory factors(IL-1β,IL-6,and TNF-α)in both groups decreased significantly after the treatment(P<0.05).The observation group had lower expression levels of serum inflammatory factors than the observation group,and the differences were statistically significant(P<0.05).Conclusion Strong-bone Decoction has a good clinical effect in the treatment of KOA.It decreases the expression levels of serum inflammatory factors.

关 键 词：强骨饮 膝骨关节炎 临床疗效 炎症因子 

分 类 号：R274.9[医药卫生—中西医结合] R684.3[医药卫生—中医骨伤科学]