中药方剂内服、外用对手部屈肌腱Ⅱ区断裂伤术后粘连的效果观察及对IL-6、IL-12、CRP水平的影响  

Effect of Oral and External Use of Traditional Chinese Medicine Prescriptions on Postoperative Adhesion of Flexor Tendon RegionⅡFracture Injury and Its Influence on Levels of Il-6,Il-12 and CRP

作　　者：赵琳莉 陈琳 李文 许玉林 梁杰 毛海郦 ZHAO Linli;CHEN Lin;LI Wen;XU Yulin;LIANG Jie;MAO Haili(Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China)

机构地区：[1]西南医科大学附属医院,四川泸州646000

出　　处：《中华中医药学刊》2023年第1期77-80,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项(2019ZX85236975)。

摘　　要：目的观察中药方剂内服、外用对手部屈肌腱Ⅱ区断裂伤术后粘连效果观察及对白细胞介素-6(inter-leukin-6,IL-6)、白细胞介素-12(inter-leukin-12,IL-12)和C-反应蛋白(C-reaction protein,CRP)水平的影响。方法选取2018年8月—2021年6月接受手部屈肌腱Ⅱ区断裂伤修复术且发生术后粘连的90例患者为观察对象,采用随机数字表将其分为对照组和观察组各45例,两组患者均给予西药治疗,观察组在西医治疗的基础上给予活血化瘀汤口服及舒筋通络方熏洗。观察两组的治疗效果、疼痛程度、手灵巧度恢复情况、炎症因子水平和治疗安全性的差异。结果观察组治疗的优良率为97.78%(44/45),明显高于对照组的82.22%(37/45),差异有统计学意义(P<0.05)。治疗前两组疼痛视觉模拟评分(VAS)差异无统计学意义(P>0.05),治疗后均显著降低,且观察组显著低于对照组(P<0.05);治疗前两组明尼苏达手灵巧度评定(minnesota manual dexterity test,MMDT)放置时间、翻转时间比较差异均无统计学意义(P>0.05),治疗后均显著缩短,且观察组显著短于对照组(P<0.05);治疗前两组IL-6、IL-12和CRP水平差异均无统计学意义(P>0.05),治疗后均显著降低,且观察组显著低于对照组(P<0.05);治疗期间两组不良反应发生率分别为2.22%、6.67%,差异无统计学意义(P>0.05)。结论中药方剂内服、外用对手部屈肌腱Ⅱ区断裂伤术后粘连的效果更佳,能够更好地改善手功能,减轻炎症,并且不会增加并发症的发生率,具有良好的应用价值。Objective To observe the effect of oral and external Chinese medicine prescriptions on postoperative adhesion of flexor tendon II region fracture injury and its influence on levels of interleukin-6(IL-6),interleukin-12(IL-12)and C-reactive protein(CRP).Methods From August 2018 to June 2021,90 patients who underwent repair of hand flexor tendonⅡarea rupture injury were selected as observation subjects.They were divided into control group and observation group by random number table,with 45 cases in each group.Both groups were treated with western medicine,and the observation group was treated with Huoxue Huayu Decoction(活血化瘀汤)orally and fumigation and washing with Shujin Tongluo Decoction(舒筋通络方)on the basis of western medicine.The therapeutic effect,pain degree,recovery of hand dexterity,levels of inflammatory factors and therapeutic safety of the two groups were observed.Results The excellent and good rate of the observation group was 97.78%,which was significantly higher than 82.22%(37/45)of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in visual analogue scale(VAS)between the two groups before treatment(P>0.05).After treatment,the scores of both groups were significantly reduced,and the score of the observation group was significantly lower than that of the control group(P<0.05).Before treatment,there was no significant difference in the placement time or turnover time of Minnesota Hand Dexterity Assessment(MMDT)between two groups(P>0.05).After treatment,those of both groups were significantly shortened,and the time of the observation group was significantly shorter than that of the control group(P<0.05).There was no significant difference in the levels of IL-6,IL-12 or CRP between two groups before treatment(P>0.05).After treatment,the levels of both groups were significantly reduced,and those of the observation group were significantly lower than those of the control group(P<0.05).During the treatment,the incidence of adver

关 键 词：肌腱 粘连 中药 方剂 

分 类 号：R274.987.2[医药卫生—中西医结合]