石斛消萎汤结合西药常规对慢性萎缩性胃炎患者血管内皮因子的调节作用研究  

Study on Regulating Effect of Shihu Xiaowei Decoction(石斛消萎汤)Combined with Western Medicine on Vascular Endothelial Factor in Chronic Atrophic Gastritis

作　　者：胡颖[1] 王鸿 赖华梅 沈丹丹 HU Ying;WANG Hong;LAI Huamei;SHEN Dandan(Xinhua Hospital Affiliated to School of Medicine,Shanghai Jiao Tong University,Shanghai 200000,China;Chongming Branch,Xinhua Hospital Afiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200000,China)

机构地区：[1]上海交通大学医学院附属新华医院,上海 [2]上海交通大学医学院附属新华医院崇明分院,上海

出　　处：《中华中医药学刊》2023年第1期175-178,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：上海市科委基础研究重点项目(13NM1401504)。

摘　　要：目的评价石斛消萎汤结合西药常规对慢性萎缩性胃炎患者血管内皮因子的调节作用研究。方法选择慢性萎缩性胃炎患者116例,随机分为两组各58例。对照组患者采用西药常规治疗,研究组在对照组治疗的基础上,口服石斛消萎汤治疗,两组患者均连续治疗1个月。比较两组治疗前后临床症状积分和治疗疗效,比较两组治疗前后胃镜病理组织评分、胃镜黏膜征象、消化不良症状和结局指标(PRO)评分,比较两组治疗前后血清学指标和血管内皮因子水平。结果研究组治疗总有效率为96.55%(56/58)高于对照组治疗总有效率(82.76%,48/58)(P<0.05);研究组治疗后临床症状积分低于对照组(P<0.05);研究组治疗后萎缩程度、肠化程度、HP感染、慢性炎性反应和活动性评分低于对照组(P<0.05);研究组治疗后胃镜黏膜征象、消化不良症状和PRO评分低于对照组(P<0.05);研究组治疗后血清学指标前列腺素E2(PGE2)、降钙素基因相关肽(CGRP)、胃蛋白酶原I(PGI)水平高于对照组(P<0.05);研究组治疗后血管内皮因子VEGF和NO水平高于对照组(P<0.05)。结论石斛消萎汤结合西药常规治疗慢性萎缩性胃炎效果确切,可有效地改善患者的临床症状,有利于体内相关血管生长因子的释放,发挥对胃黏膜的保护作用,进而改善病理组织学病变,促进黏膜修复,提高治疗疗效和患者的生活质量,值得临床进一步推广应用。Objective To evaluate the effect of Shihu Xiaowei Decoction(石斛消萎汤)combined with conventional western medicine on the regulation of vascular endothelial factors in patients with chronic atrophic gastritis.Methods A total of 116 cases of patients with chronic atrophic gastritis,according to random number table method,were divided the patients into two groups,58 cases in each group.The control group was treated with conventional western medicine,and the study group was treated with Shihu Xiaowei Decoction orally on the basis of the treatment in the control group.The two groups were treated continuously for 1 month.Clinical symptom scores and therapeutic efficacy were compared between the two groups before and after treatment.Gastroscopic pathological tissue scores,endoscopic mucosal signs,dyspepsia symptoms and patient reported outcome(PRO)scores were compared between the two groups before and after treatment.Serological indexes and vascular endothelial factor levels were compared between the two groups before and after treatment.Results The total effective rate of the study group was 96.55%(56/58),higher than that of the control group(82.76%,48/58)(P<0.05).The clinical symptom score of the study group was lower than that of the control group(P<0.05).The scores of atrophy,intestinal metaplasia,HP infection,chronic inflammatory response and activity in the study group were lower than those in the control group(P<0.05).The endoscopic mucosal signs,dyspepsia symptoms and PRO score in the study group were lower than those in the control group after treatment(P<0.05).Serological indexes of prostaglandin E2(PGE2),calcitonin gene related peptide(CGRP)and pepsinogen I(PGI)in the study group were higher than those in the control group(P<0.05).The levels of vascular endothelial factor(VEGF)and nitric oxide(NO)in the study group were higher than those in the control group(P<0.05).Conclusion Shihu Xiaowei Decoction combined with conventional western medicine treatment has exact effect on chronic atrophic gastritis.It

关 键 词：石斛消萎汤 慢性萎缩性胃炎 西药常规 血管内皮因子 生活质量 

分 类 号：R259.733.2[医药卫生—中西医结合]