金骨莲胶囊联合甲钴胺对腰椎间盘突出症血清疼痛递质及腰椎功能的影响研究  

Effect of Jingulian Capsules(金骨莲胶囊)Combined with Mecobalamin on Serum Pain-related Transmitters and Lumbar Function in Patients with Lumbar Disc Herniation

作　　者：施星臣[1] 贺彦玢 滕月鹏[1] SHI Xingchen;HE Yanbin;TENG Yuepeng(Lanzhou Second People's Hospital,Lanzhou 730046,Gansu,China)

机构地区：[1]兰州市第二人民医院,甘肃兰州730046

出　　处：《中华中医药学刊》2023年第1期209-213,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：甘肃省自然科学基金(1506RJYA315)。

摘　　要：目的探究金骨莲胶囊联合甲钴胺对腰椎间盘突出症患者血清疼痛递质及腰椎功能的影响研究。方法采用简单随机分组法将2018年1月—2020年12月医院门诊及部分住院患者中的107例腰椎间盘突出症患者分为观察组(55例)与对照组(52例)。对照组给予甲钴胺,观察组则在对照组的基础上联合使用金骨莲胶囊。观察组两组患者血清中神经肽Y(neuropeptide Y,NPY)、P物质(substance P,SP)、5-羟色胺(5 serotonin,5-HT)、血清降钙素基因相关肽(calcitonin gene related pepitde,CGRP),前列腺E_(2)(dinoprostone,ProstinE,PGE_(2))水平状态。使用视觉模拟评分法(visualanaloguescale,VAS)对患者进行主观上疼痛评分,运用日本骨科协会评估治疗分数(Japanese orthopaedic association Scores,JOA评分)评估患者的腰椎功能,Oswestry腰椎功能障碍指数(oswestry disability index,ODI)变化,及比较两组患者不良反应发生率与有效率。结果治疗前两组患者NPY、CGRP、PGE_(2)、SP、5-HT水平差异无显著统计学意义(P>0.05)。两组患者治疗后30 d、60 d,观察组NPY、CGRP、PGE_(2)、SP、5-HT水平显著低于对照组(P<0.05)。两组患者治疗前VAS评分差异无统计学意义(P>0.05)。两组患者在治疗后30 d、60 d时,观察组VAS评分显著低于对照组(P<0.05)。治疗前观察组主要症状、临床体征、日常活动、JOA评分与对照组差异无统计学意义(P>0.05)。治疗后30 d、60 d观察组主要症状、临床体征、日常活动、JOA评分较对照组显著提高(P<0.05)。治疗前观察组ODI与对照组无显著差异(P>0.05)。治疗后观察组ODI较对照组显著降低(P<0.05)。对照组的不良反应发生率(9.61%,5/55)略高于观察组(9.09%,5/52)但差异无显著统计学意义(P>0.05)。观察组的总有效率(89.09%,49/65)略高于对照组(80.76%,42/52),但两组总有效率差异无统计学意义(P>0.05)。结论金骨莲胶囊联合甲钴胺对降低腰椎间盘突出症患者血清疼痛递质NPY、SP�Objective To investigate the clinical efficacy of Jingulian Capsules(金骨莲胶囊)combined with mecobalamin on serum contents of pain-related transmitters and lumbar function in patients with lumbar disc herniation.Methods A total of 107 patients with lumbar disc herniation from January 2018 to December 2020 were observed(55 cases)and control(52 cases).The control group was given methocobalamin,while the observation group combined Jingulian Capsules on the basis of the control group.The serum levels of neuropeptide Y(NPY),substance P(SP),5 serotonin(5-HT),serum calcitonin gene-related peptide(CGRP)and prostate E_(2)(PGE_(2))were observed.The subjective pain scores were explored by using Visual Analogue Scale(VAS),Japanese Orthopaedic Association Scores(JOA score),Oswestry Disability Index(ODI)changes,and the incidence and efficiency of adverse reactions were compared between the two groups.Results Serum levels of NPY,CGRP,PGE_(2),SP and 5-HT yielded no statistical difference at the baseline(P>0.05),while the levels of NPY,CGRP,PGE_(2),SP and 5-HT were significantly lower in the observation group than those in the control group at post-treatment 30 d and 60 d(P<0.05).Baseline VAS score had no significant difference between two groups(P>0.05),while the scores at post-treatment 30 d and 60 d were significantly lower in the observation group than those in the control group(P<0.05).No statistical difference was found in the scores of major symptoms,clinical signs,daily activities or JOA between two groups at the baseline(P>0.05),while the scores at post-treatment 30 d and 60 d were significantly higher in the observation group than those in the control group(P<0.05).ODI score demonstrated no significant difference between two groups at the baseline(P>0.05),while the score was significantly lower in the observation group than that in the control group at post-treatment 30 d and 60 d(P<0.05).The adverse reaction rate was 9.61%(5/59)in the control group,which was slightly higher than 9.09%(5/52)in the observation grou

关 键 词：金骨莲胶囊 甲钴胺 腰椎间盘突出症 疼痛递质 腰椎功能 

分 类 号：R274.981.53[医药卫生—中西医结合]