核因子-红细胞2相关因子2/血红素氧化酶信号通路在急性肺损伤中的作用  

Protection effects of the nuclear factor‑erythroid 2 related factor 2/heme oxygenase 1 signaling axis in acute lung injury

作　　者：张录 赵伟红[1] 钱克俭[2] 罗佛全 Zhang Lu;Zhao Weihong;Qian Kejian;Luo Foquan(Department of Anesthesiology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Intensive Care Unit,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Department of Anesthesiology,Zhejiang Provincial Peo-ple's Hospital,Hangzhou 310014,China)

机构地区：[1]南昌大学第一附属医院麻醉科,南昌330006 [2]南昌大学第一附属医院重症医学科,南昌330006 [3]浙江省人民医院麻醉科,杭州310014

出　　处：《国际麻醉学与复苏杂志》2022年第11期1228-1232,共5页International Journal of Anesthesiology and Resuscitation

摘　　要：急性肺损伤(acute lung injury,ALI)是由肺内或肺外致病因素导致肺上皮细胞和血管内皮细胞损伤,引起氧合功能障碍的一种急性炎症性疾病。ALI的发病机制被认为与炎症反应、氧化应激、细胞凋亡等病理生理过程相关,但其具体的调控通路尚不清楚。文章着重介绍了核因子-红细胞2相关因子2(nuclear factor-erythroid 2 related factor 2,Nrf2)/血红素氧化酶1(heme oxygenase 1,HO-1)信号通路在ALI中的作用及其机制的研究进展,综述Nrf2/HO-1信号通路在炎症反应、细胞凋亡、自噬、细胞焦亡及铁死亡中的作用,从而为临床治疗ALI提供新思路。Acute lung injury(ALI)is an acute inflammatory disease caused by the damage of pulmonary epithelial cells and vascular endothelial cells induced by pathogenic factors inside or outside the lung,which causes oxygenation dysfunction.The patho⁃genesis of ALI is believed to be related to pathophysiological processes such as inflammation,oxidative stress,and apoptosis,but its specific regulatory pathway is still unclear.This article focuses on the role of nuclear factor⁃erythroid 2 related factor 2(Nrf2)/heme oxy⁃genase 1(HO⁃1)signal pathway in ALI and the research progress of its mechanism.It reviews the role of the Nrf2/HO⁃1 signal pathway in an inflammatory response,cell apoptosis,autophagy,cell scorch,and iron death to provide a new idea for the clinical treatment of ALI.

关 键 词：核因子-红细胞2相关因子2 血红素氧化酶1 急性肺损伤 氧化应激 炎症 

分 类 号：R563.8[医药卫生—呼吸系统]