职业环境中铂类抗癌药物测定的感应耦合等离子体质谱法  

Determination of platinum anticancer drugs in occupational settings by ICP-MS

作　　者：林怡然 梅小红 黄小红[2] 李添娣 林怡 张文 Lin Yiran;Mei Xiaohong;Huang Xiaohong;Li Tiandi;Lin Yi;Zhang Wen(Department of Physical and Chemical Testing of Shenzhen Prevention and Treatment center for Occupational Diseases,Shenzhen 518020,China;Nursing Department of Longgang Central Hospital of Shenzhen,Shenzhen 518117,China)

机构地区：[1]深圳市职业病防治院理化检测所,深圳518020 [2]深圳市龙岗中心医院护理部,深圳518117

出　　处：《中华劳动卫生职业病杂志》2022年第12期950-951,共2页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的建立环境中铂类抗癌药物的感应耦合等离子体质谱法(ICP-MS)测定方法。方法环境物表中的铂类抗癌药物经擦拭采集纯水洗脱,离心取上清进电感耦合等离子体质谱进行检测。结果本方法测定浓度范围在0~8.0μg/L内线性范围良好,相关系数为1.000,方法检出限为0.0006μg/L,定量下限为0.002μg/L,方法精密度在0.9%~1.3%,样品加标回收率在97.0%~98.5%。结论本方法对铂类抗癌药物测定检出限低,准确度、精密度高,样品前处理简单,适用于环境物表中的铂类抗癌药物的测定。Objective To establish an inductively coupled plasma mass spectrometry(ICP-MS)for platinum antineoplastic drugs in the environment.Methods The platinum antineoplastic drugs in the environmental table were eluted by wiping and collecting pure water,and the supernatant was taken by centrifugation and inductively coupled plasma mass spectrometry for detection.Results The concentration range of 0-8.0μg/L was good,the correlation coefficient was 1.000,the detection limit was 0.0006μg/L,the lower quantitative limit was 0.002μg/L,the method precision was between 0.9%-1.3%,and the sample standard recovery rate was between 97.0%-98.5%.Conclusion This method has low detection limit,high accuracy and precision,and simple sample pretreatment,which is suitable for the determination of platinum antineoplastic drugs in environmental tables.

关 键 词：质谱法 感应耦合等离子体 环境 物体表面 铂类抗癌药物 

分 类 号：R979.1[医药卫生—药品]