基于皮层分析针刺神门穴对睡眠剥夺后低频振荡振幅的影响  

Effect of acupuncture at Shenmen (HT 7) on amplitude of low frequency fluctuation after sleep deprivation based on cortical analysis

作　　者：姚昊 郑入文[1] 郑思思 冯正田 冯思同 刘鑫子 蔡永丽 宁艳哲 YAO Hao;ZHENG Ruwen;ZHENG Sisi;FENG Zhengtian;FENG Sitong;LIU Xinzi;CAI Yongli;NING Yanzhe(Department of acupuncture,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078;National Clinical Research Center for Mental Disorders&National Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University;Advanced Innovation Center for Human Brain Protection,Capital Medical University)

机构地区：[1]北京中医药大学东方医院针灸科,北京100078 [2]首都医科大学附属北京安定医院,国家精神医学中心,国家精神心理疾病临床研究中心,精神疾病诊断与治疗北京市重点实验室 [3]人脑保护高精尖创新中心,首都医科大学

出　　处：《现代中医临床》2022年第6期1-5,共5页Modern Chinese Clinical Medicine

基　　金：国家自然科学基金项目(No.81904120);北京市医院管理中心青年人才培养“青苗”计划(No.QML20201901);北京市医院管理中心临床医学发展专项经费资助(No.ZYLX202129);北京医院管理中心登峰人才(No.DFL20191901)。

摘　　要：目的 基于皮层分析针刺神门穴对24 h睡眠剥夺后大脑相关脑区低频振荡振幅(amplitude of low frequency fluctuation, ALFF)活动的影响。方法 30名健康受试者经过24 h睡眠剥夺后,针刺双侧神门穴,在睡眠剥夺前、后和针刺神门穴后各进行1次功能磁共振扫描。同时基于皮层采用DPABISurf软件进行预处理并计算睡眠剥夺前、后和针刺后全脑的ALFF值。结果 与睡眠剥夺前比,睡眠剥夺后ALFF值升高的脑区主要包括双侧中央后回、双侧中央前回、右侧中央旁小叶;ALFF值降低的脑区主要包括双侧角回、双侧后扣带回、右侧额下回。与睡眠剥夺后相比,针刺神门穴后ALFF值升高的脑区包括右侧眶额上回和额下回;ALFF值降低的脑区包括双侧中央后回、左侧中央前回、双侧中央旁小叶和左侧脑岛。针刺后与睡眠剥夺前相比,未发现ALFF值明显异常的脑区。结论 针刺神门穴对睡眠剥夺后多个与认知功能和情绪调节相关脑区的功能活动异常起调节作用,这可能是针刺干预睡眠剥夺的效应机制。Objective To explore the effect of acupuncture at Shenmen(HT 7)on the activity of amplitude of low frequency fluctuation(ALFF) after 24 h sleep deprivation based on cortical analysis.Methods A total of 30 healthy subjects were recruited, and received the needling at bilateral Shenmen acupoints(HT 7) after 24 h sleep deprivation. The functional magnetic resonance scanning(fMRI) was performed before and after sleep deprivation, and after acupuncture at HT 7. Meanwhile, DPABISurf was used to preprocess and calculate the ALFF values.Results Compared with that before sleep deprivation, the brain regions with increased ALFF values after sleep deprivation mainly included bilateral posterior central gyrus, bilateral anterior central gyrus and right paracentral lobule, meanwhile the brain regions with decreased ALFF values mainly include bilateral angular gyrus, bilateral posterior cingulate gyrus and right inferior frontal gyrus. Compared with that after sleep deprivation, the brain regions with increased ALFF values after needling at HT 7 mainly included the right superior orbitofrontal gyrus and inferior frontal gyrus, and the brain regions with decreased ALFF values included the bilateral posterior central gyrus, left anterior central gyrus, bilateral paracentral lobules, and left insula. Compared with that before sleep deprivation, there was no significant change in ALFF value in brain regions after acupuncture.Conclusions Acupuncture at HT 7 can modulate the abnormal functional activities of multiple brain regions related to cognitive functions and emotional regulation after sleep deprivation, which may be the effect mechanism of acupuncture on sleep deprivation.

关 键 词：睡眠剥夺 针刺 神门穴 功能磁共振 低频振荡振幅 

分 类 号：R2-03[医药卫生—中医学]