鳖甲软肝配方颗粒联合恩替卡韦治疗慢性乙型肝炎肝纤维化的疗效观察  

Observation on effect of Biejia Ruangan Formula Granules combined with Entecavir in the treatment of chronic hepatitis B liver fibrosis

作　　者：余松[1] 何杰[1] YU Song;HE Jie(Department of Infectious Diseases,the First People’s Hospital of Huzhou,Huzhou,313000,China)

机构地区：[1]湖州市第一人民医院感染科,湖州313000

出　　处：《北京中医药》2022年第12期1360-1363,共4页Beijing Journal of Traditional Chinese Medicine

基　　金：湖州市科学技术局资助项目(2018GYB08)。

摘　　要：目的 观察鳖甲软肝配方颗粒联合恩替卡韦治疗气阴虚损、瘀血阻络型慢性乙型肝炎肝纤维化的临床疗效。方法将80例气阴虚损、瘀血阻络型慢性乙型肝炎肝纤维化患者随机分为对照组和观察组,各40例。对照组口服恩替卡韦分散片,观察组在对照组治疗的基础上口服鳖甲软肝配方颗粒,2组均治疗6个月。比较2组治疗前后的肝功能指标、肝脏硬度值(LSM)、血清肝纤维化指标、病毒学指标及安全性指标。结果 治疗后,2组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)均低于治疗前(P<0.05),2组ALT、AST、TBIL差异无统计学意义(P>0.05)。治疗后,2组LSM均低于治疗前(P<0.05),且观察组LSM低于对照组(P<0.05)。治疗后,2组血清肝纤维化指标均低于治疗前(P<0.05),且观察组血清肝纤维化指标低于对照组(P<0.05)。治疗后,2组乙型肝炎病毒DNA (HBV-DNA)阴转率、乙型肝炎病毒e抗原(HBeAg)阴转率比较差异无统计学意义(P>0.05)。结论 鳖甲软肝配方颗粒联合恩替卡韦治疗气阴虚损、瘀血阻络型慢性乙型肝炎肝纤维化患者,能有效减轻肝纤维化程度。Objective To observe the clinical effect of Biejia Ruangan Formula Granules combined with Entecavir in treating chronic hepatitis B liver fibrosis due to deficiency of qi and yin and obstruction of collaterals by blood stasis.Methods EEighty patients with chronic hepatitis B liver fibrosis of deficiency of qi and yin type and obstruction of collaterals by blood stasis type were randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with orally taking Entecavir Dispersible Tablets,while the observation group was treated with Biejia Ruangan Formula Granules on the basis of the control group.Both groups were treated for 6 months.The indexes of liver function,liver hardness(LSM),serum liver fibrosis,virology and safety were compared before and after treatment.Results After treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST) and total bilirubin(TBIL) in the two groups were lower than those before treatment(P 0.05).After treatment,the LSM of patients in both groups was lower than that before treatment(P0.05).Conclusion Biejia Ruangan Formula Granules combined with Entecavir can effectively reduce the degree of liver fibrosis in treating chronic hepatitis B patients with liver fibrosis of deficiency of qi and yin type and obstruction of collaterals by blood stasis type.

关 键 词：鳖甲软肝配方颗粒 恩替卡韦 慢性乙型肝炎 肝纤维化 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]