GRP94的结构、生理功能及与疾病的关系  

Structure,physiological function,and relationship of GRP94 to disease

作　　者：叶佳纯 王英[1] YE Jiachun;WANG Ying(The Affiliated Lihuili Hospital,Ningbo University,Ningbo 315040,China)

机构地区：[1]宁波大学附属李惠利医院,宁波315040

出　　处：《生命的化学》2022年第11期1975-1984,共10页Chemistry of Life

基　　金：宁波市自然科学基金项目(2019A610343)。

摘　　要：葡萄糖调节蛋白94(glucose-regulated protein 94,GRP94)是分子伴侣热激蛋白90(heat shock protein 90,Hsp90)的内质网亚型。生理条件下,它在调节生物生理功能方面起着协助膜蛋白折叠、维持钙稳态以及调节免疫系统功能的重要作用。在病理条件下,过表达GRP94将影响某些疾病如肿瘤及病毒性感染的发生发展过程,因此识别参与疾病的GRP94客户蛋白以及开发GRP94小分子靶向抑制剂对相关疾病的治疗具有积极意义。本文就GRP94的结构、功能及其在相关疾病中发挥的作用的研究进展展开综述。Glucose-regulated protein 94(GRP94) is an endoplasmic reticulum isoform of the molecular chaperone heat shock protein 90(Hsp90).Under physiological conditions,it plays an important role in regulating biological physiological functions by assisting membrane protein folding,maintaining calcium homeostasis,and regulating the function of the immune system.Under pathological conditions,overexpression of GRP94 will affect the development of certain diseases such as tumors and viral infections,therefore the identification of GRP94 client proteins involved in diseases and developing specific small-molecule inhibitors of GRP94 are of positive significance for the treatment of related diseases.This paper reviews the structure,function,and role of GRP94 in related diseases.

关 键 词：病毒性疾病 GRP94 分子伴侣 肿瘤 

分 类 号：R341[医药卫生—基础医学]