齐考诺肽在癌痛与其他顽固性疼痛治疗中的应用:文献综述  

Ziconotide:application in cancer pain and other refractory chronic pain

作　　者：刘俊鹏 任玉娥[1] 刘广召[1] Liu Junpeng;Ren Yu′e;Liu Guangzhao(Department of Painology,Second Hospital of Hebei Medical University,Shijiazhuang City,Hebei Province 050000,China)

机构地区：[1]河北医科大学第二医院疼痛科,石家庄市050000

出　　处：《中华疼痛学杂志》2022年第5期691-697,共7页Chinese Journal Of Painology

摘　　要：齐考诺肽(ZCN)是一种N型电压敏感性钙通道阻滞剂,是唯一一种被美国食品药品管理局(FDA)批准用于治疗全身镇痛药不能耐受或无效的顽固性疼痛的鞘内镇痛药。本文对齐考诺肽的作用机制、药效学、药代学和临床应用进行介绍,希望能为临床应用提供有益的参考。Ziconotide is a N-type calcium channel antagonist,and is the only non-opioid intrathecal analgesic approved by FDA for application in patients with severe chronic pain and intolerant or refractory to other treatments.This article reviews the mechanism,pharmacodynamics,pharmacokinetics and clinical application of ziconotide to provide reference for clinical application.

关 键 词：齐考诺肽 钙通道阻滞剂 鞘内镇痛药 癌症疼痛 

分 类 号：R979.1[医药卫生—药品]