奇壬醇的功能及抗炎作用机制研究进展  

The research progress on the function and anti-inflammatory mechanisms of kirenol

作　　者：张梦 沈小芳 翟立红[1,2] 肖娟 ZHANG Meng;SHEN Xiao-Fang;ZHAI Li-Hong;XIAO Juan(Department of Molecular Medicine Laboratory,Hubei University of Arts and Science,Xiangyang 441053,China;Institute of Neuroscience and Brain Diseases,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang 441021,China)

机构地区：[1]湖北文理学院医学部分子医学实验室,襄阳441053 [2]湖北文理学院附属医院襄阳市中心医院,神经科学与脑科学研究所,襄阳441021

出　　处：《生命科学》2022年第12期1550-1558,共9页Chinese Bulletin of Life Sciences

基　　金：襄阳市科技局项目(No.2021YL45,2021YL48);2021年湖北文理学院大学生创新创业训练计划项目(No:202110519002)。

摘　　要：奇壬醇(kirenol,kir)是从传统抗风湿药豨莶草中提取的活性成分,因其具有广泛的药理学活性,近几年引起国内外科研工作者的研究兴趣。现代临床前研究证实kir具有多种生物学活性,包括抑制细胞生长、促凋亡、抗炎、心脏保护、抗光老化、抗脂肪生成、抗菌、改善肌肉功能、抗关节炎、促进骨折和伤口愈合等。大量研究发现kir通过调节NF-κB和Nrf2在各种体内和体外疾病模型中发挥抗炎作用,提示抗炎是kir的主要生物学功能。该文综合分析近年来发表的研究成果,总结kir的生物学功能和抗炎分子机制、应用前景及不足,为kir的下一步基础研究和临床应用研究提供线索。Kirenol(kir)is an active ingredient extracted from Herba Siegesbeckiae which is a traditional antirheumatic herb in China.In recent years,kir has attracted the interests of researchers for its extensive pharmacological activity.Modern preclinical studies have confirmed that kir has a variety of biological activities,including inhibiting cell growth,promoting apoptosis,anti-inflammation,cardiac protection,anti-photoaging,antiadipogenesis,antibacterial,muscle improvement,anti-arthritis,promoting fracture and wound healing,etc.Many studies have found that kir plays an anti-inflammatory role in vivo and in vitro by regulating NF-κB and Nrf2,suggesting that anti-inflammation is the main biological function of kir.This paper comprehensively analyzed the research results published in recent years,summarized the biological function and anti-inflammatory molecular mechanisms of kir,and analyzed its application prospects and limitations,in order to provide clues for the future preclinical and clinical researches on kir.

关 键 词：奇壬醇 功能 抗炎 分子机制 

分 类 号：R96[医药卫生—药理学]