糖尿病减弱七氟醚后处理心肌保护作用及其机制研究进展  

Research progress of diabetes attenuates the cardioprotective effect of sevoflurane postconditioning and its mechanisms

作　　者：夏瑞 王蓉[1,2] 姚尚龙[1,2] 王婷婷[1,2] Xia Rui;Wang Rong;Yao Shanglong;Wang Tingting(Department of Anesthesiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Institute of Anesthesia and Critical Care,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院麻醉科,武汉430022 [2]华中科技大学同济医学院附属协和医院麻醉与重症医学研究所,武汉430022

出　　处：《国际麻醉学与复苏杂志》2022年第12期1306-1310,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(81770824)。

摘　　要：糖尿病状态下,七氟醚后处理(sevoflurane postconditioning,SPostC)的心肌保护作用减弱。文章就近年来SPostC在心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)中作用的最新研究进展进行综述,着重讨论糖尿病减弱SPostC心肌保护作用的分子机制,其中包括磷脂酰肌醇⁃3⁃激酶(phosphoinositide 3⁃kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)、缺氧诱导因子⁃1α(hypoxia⁃inducible factor⁃1α,HIF⁃1α)和酪氨酸蛋白激酶2(janus kinase 2,JAK2)/信号转导因子和转录激活因子3(signal transducer and activator of transcriptions 3,STAT3)等多条信号通路的受损及氧化应激和动力相关蛋白1(dy⁃namin related protein 1,DRP1)等诱导的线粒体损伤,讨论了恢复SPostC对糖尿病心肌保护作用的策略,以期为恢复糖尿病心肌对SPostC的敏感性提供新的治疗靶点。The cardioprotective effect of sevoflurane postconditioning(SPostC)is weakened in the diabetic state.In this review,we summarize the research progress on the roles of SPostC in myocardial ischemia reperfusion injury(MIRI)and focus on the molecular mechanisms by which diabetes attenuates its cardioprotective effect.Numerous impaired signaling pathways are researched,including phosphoinositide 3⁃kinase(PI3K)/protein kinase B(Akt),hypoxia⁃inducible factor⁃1α(HIF⁃1α)and janus kinase 2(JAK2)/signal transduction factor and transcription activator 3(STAT3)signaling.In addition,oxidative stress and dynamin related protein 1(DRP1)induced mitochondrial dysfunction are also involved in heart tissue damage.In addition,the present review discusses the strate⁃gies for restoring the protective effect of SpostC on diabetic myocardium,which may provide a new therapeutic target.

关 键 词：糖尿病 缺血再灌注损伤 心肌 七氟醚 后处理 心肌保护 分子机制 

分 类 号：R614[医药卫生—麻醉学]