苏州市某社区老年肌少症人群血脂状况及其与肌少症发生的相关性  

Association between blood lipid profile and sarcopenia in elderly people in one community in Suzhou

作　　者：李娇娇[1] 陈雅[1] 张慧[1,2] 黎梦丽[1,3] 王丽 LI Jiao-Jiao;CHEN Ya;ZHANG Hui;LI Meng-Li;WANG Li(School of Nursing,Suzhou Medical College of Soochow University,Suzhou 215006,Jiangsu Province,China;School of Nursing,Suzhou Vocational Health College,Suzhou 215009,Jiangsu Province,China;School of Nursing,Hong Kong Polytechnic University,Hong Kong 999077,China)

机构地区：[1]苏州大学苏州医学院护理学院,江苏苏州215006 [2]苏州卫生职业技术学院,江苏苏州215009 [3]香港理工大学护理学院,中国香港999077

出　　处：《中华老年多器官疾病杂志》2023年第1期6-11,共6页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：苏州大学人文社会科学科研项目(21XM2012);国家自然科学基金青年项目(81501944)。

摘　　要：目的探讨血脂水平与肌少症诊断指标及肌少症发生的相关性。方法采用方便抽样,收集1534例苏州市社区老年人的一般资料、血脂水平及身体成分,进行握力及6米步速测试,依据亚洲肌少症工作组2019年诊断标准,分为肌少症人群与非肌少症人群,比较两类人群血脂状况差异,探讨血脂与肌少症相关性。采用SPSS 23.0软件进行数据分析。根据数据类型,组间比较分别采用t检验、Mann-Whitney U检验,χ^(2)检验以及相关和回归分析。结果与非肌少症人群相比,肌少症人群的极低密度脂蛋白胆固醇[(0.49±0.18)和(0.53±0.29)mmol/L]、甘油三酯[TG,(1.57±0.92)和(1.76±1.22)mmol/L]、甘油三酯/高密度脂蛋白胆固醇比值[TG/HDL-C,(1.26±1.10)和(1.52±1.39)]显著较低(均P<0.05);而HDL-C[(1.45±0.37)和(1.31±0.32)mmol/L;P<0.01]、总胆固醇[TC,(5.17±1.03)和(4.97±0.96)mmol/L;P<0.05]显著更高;高TG发生率[29.10%(55/189)和36.28%(488/1345);P<0.05]较低;高TC发生率[48.15%(91/189)和36.88%(496/1345);P<0.01]更高。同时,四肢骨骼肌质量指数(ASMI)与HDL-C及TC水平呈负相关(r=-0.289、-0.202,P<0.001)。Logistic回归分析显示,年龄更大(OR=1.121,95%CI 1.091~1.152)、HDL-C更高(OR=2.133,95%CI 1.206~3.773)是肌少症发生的危险因素(P<0.01),性别为男性(OR=0.539,95%CI 0.372~0.781)、合并其他慢性病(OR=0.599,95%CI 0.413~0.868)是肌少症发生的保护因素(P<0.01)。结论HDL-C升高与骨骼肌质量下降相关,是肌少症发生的危险因素。社区体检中对于HDL-C水平较高老年人更应关注其肌肉质量和功能变化,必要时进行肌量下降和肌少症筛查。Objective To explore the correlation of blood lipid profile with the diagnostic indicators of sarcopenia and its occurrence.Methods A total of 1534 elderly people in a community in Suzhou were recruited using convenience sampling method,and their general information,blood lipid levels,and body composition were collected.Handgrip strength and six-meter usual gait speed were measured.According to the Asian Sarcopenia Working Group 2019 Consensus Update on Sarcopenia Diagnosis,they were divided into sarcopenia group and non-sarcopenia group.The two groups were compared in blood lipid profile to explore its correlation with sarcopenia.SPSS statistics 23.0 was used for statistical analysis.Data comparison between two groups was perfomed using t test,Mann-Whitney U test or χ^(2) test depending on data type.Crrelation and regression analysis were also performed.Results The very low-density lipoprotein cholesterol[(0.49±0.18)vs(0.53±0.29)mmol/L],triglyceride(TG)[(1.57±0.92)vs(1.76±1.22)mmol/L],and triglyceride/high-density lipoprotein cholesterol ratio(TG/HDL-C)[(1.26±1.10)vs(1.52±1.39)]were significantly lower in the sarcopenic population than the non-sarcopenic population(P<0.05).The HDL-C[(1.45±0.37)vs(1.31±0.32)mmol/L;P<0.01]and total cholesterol(TC)[(5.17±1.03)vs(4.97±0.96)mmol/L;P<0.05]were significantly higher in the sarcopenic population than the non-sarcopenic population.Compared with non-sarcopenic population,the incidence of high TG[29.10%(55/189)vs 36.28%(488/1345);P<0.05]in sarcopenic population was lower,and that of high TC[48.15%(91/189)vs 36.88%(496/1345);P<0.01]was significantly higher.At the same time,the appendicular skeletal muscle mass index was negatively correlated with the level of HDL-C and TC(r=-0.289,-0.202;P<0.001).Logistic regression analysis showed that advanced age(OR=1.121,95%CI 1.091-1.152)and high HDL-C level(OR=2.133,95%CI 1.206-3.773)were risk factors for sarcopenia(P<0.01),and that male gender(OR=0.539,95%CI 0.372-0.781)and comorbidity with other chronic diseases(OR=0.599,9

关 键 词：老年人 血脂 肌少症 骨骼肌质量 

分 类 号：R589.2[医药卫生—内分泌]