急性肌少症的研究进展  

Research progress of acute sarcopenia

作　　者：刘丹丹 谭玲玲[3] 杨茗 LIU Dan-Dan;TAN Ling-Ling;YANG Ming(Center of Gerontology and Geriatrics,Western China Hospital,Sichuan University,Chengdu 610041,China;Department of Geriatrics,Hefei Second People's Hospital,Hefei 230011,China;General Department,First People's Hospital of Longquanyi District,Chengdu 610199,China;National Clinical Research Center for Geriatrics,Western China Hospital,Sichuan University,Chengdu 610041,China;Precision Medicine Research Center,Western China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院老年医学中心,成都610041 [2]合肥市第二人民医院老年医学科,合肥230011 [3]成都市龙泉驿区第一人民医院综合科,成都610199 [4]四川大学华西医院国家老年疾病临床医学研究中心,成都610041 [5]四川大学华西医院精准医学研究中心,成都610041

出　　处：《中华老年多器官疾病杂志》2023年第1期71-75,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：四川省科技厅重点研发计划(2020YFS0573)。

摘　　要：急性肌少症是指持续时间少于6个月的肌少症,常由急性应激事件(如急性疾病、手术、创伤等)诱发。作为一种新近被认识和定义的综合征,急性肌少症概念的提出不过数年,尚未引起学界广泛关注。急性肌少症与患者不良预后密切相关,增加重症监护室入住率,延长机械通气时间和住院时间,并增加死亡风险。其诊断标准是在肌少症诊断标准基础上联合诱因和发病时间。目前国内外对急性肌少症研究甚少,其发病机制尚不清楚,可能与炎症、卧床、营养不良、激素水平等相关。急性肌少症的干预措施主要包括运动锻炼、营养干预和神经肌肉电刺激,目前还没有成熟的治疗药物。Acute sarcopenia is defined as sarcopenia lasting less than 6 months and is usually a result of acute stresses(acute disease,surgery,trauma,etc.).The condition,a concept proposed only a few years ago,is a newly recognized and defined syndrome and has not yet recieved much attention in the research community.Acute sarcopenia is strongly associated with poor health-related prognoses,increasing intensive care unit admissions,prolonging mechanical ventilation and hospitalization,and increasing the risk of death.Its diagnosis is based on the diagnostic criteria of sarcopenia combined with acute stresses and the time of onset.To date,few studies focus on acute sarcopenia,and its pathogenesis remains unclear,which is probably related to inflammation,being bedridden,malnutrition,and hormonal levels.Potential interventions for acute sarcopenia include exercise,nutritional interventions,and neuromuscular electrical stimulation,but no therapeutic drugs are available.

关 键 词：肌少症 骨骼肌衰老 肌肉衰减综合征 骨骼肌减少症 

分 类 号：R592[医药卫生—老年医学]