关苍术的化学成分研究  

Chemical Constituents of Atractylodes Japonica

作　　者：付起凤[1] 马丹娜 刘宁雨 刘艳[2] 韩华[2] 金阳[2] 王萍 周媛媛[2] FU Qifeng;MA Danna;LIU Ningyu;LIU Yan;HAN Hua;JIN Yang;WANG Ping;ZHOU Yuanyuan(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Key Laboratory of Basic and Application Research of Beiyao,Ministry of Education,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang Academy of Traditional Chinese Medicine,Harbin 150036,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学,教育部北药基础与应用研究重点实验室,黑龙江哈尔滨150040 [3]黑龙江省中医药科学院,黑龙江哈尔滨150036

出　　处：《中医药信息》2023年第2期7-10,共4页Information on Traditional Chinese Medicine

基　　金：黑龙江省自然科学基金项目(LH2019H048);黑龙江省博士后科研启动金资助项目(LBH-Q16207);黑龙江中医药大学新药研究基金(2018xy02);黑龙江省“头雁”团队支持项目(黑龙江省头雁行动领导小组文件[2019]5号)。

摘　　要：目的:研究关苍术的化学成分。方法:运用硅胶柱色谱、Sephadex LH-20柱色谱、中压液相色谱和半制备高效液相色谱等方法对关苍术中化学成分进行分离纯化,结合理化性质及MS、NMR等波谱数据对化学成分进行结构鉴定。结果:从关苍术药材中分离并鉴定了12个化合物,分别鉴定为2-[(2E)-3,7-二甲基-2,6-辛二烯基]-6-甲基-2,5-环己二烯-1,4-二酮(1)、邻苯二甲酸二丁酯(2)、邻苯二甲酸二异丁酯(3)、8,9,10-三羟基百里香酚(4)、α-菠甾醇(5)、蒲公英萜醇乙酸酯(6)、β-木香酸(7)、1,8-桉叶素(8)、8,11-十八碳二烯酸甲酯(9)、对羟基苯乙酸甲酯(10)、3-羟基-4-乙酰基苯甲酸(11)和异丁香酚甲醚(12)。结论:12个化合物均为首次从关苍术中分离得到。Objective:To study the chemical constituents of Atractylodes Japonica.Methods:The chemical constituents of Atractylodes Japonica were separated and purified with silica column chromatography,Sephadex LH-20 column chromatography,medium pressure liquid chromatography and semi-preparative high preformance liquid chromatography(HPLC),and their structures were identified by the physiochemical properties,MS and NMR spectroscopic data.Results:Twelve compounds were obtained from Atractylodes Japonica and identified as 2-[(2E)-3,7-dimethy-2,6-octadienyl]-6-methyl-2,5-cyclohexadiene-1,4-dione(1),dibutyl phthalate(2),diisobutyl phthalate(3),8,9,10-trihydroxythymol(4),α-bessisterol(5),taraxeryl acetate(6),β-costusic acid(7),1,8-cineole(8),8,11-octadecadienoic acid methyl ester(9),methyl p-hydroxyphenylacetate(10),3-hydroxy-4-acetyl benzoic acid(11),and isoeugenol methyl ether(12).Conclusion:Twelve compounds are isolated from Atractylodes Japonica for the first time.

关 键 词：关苍术 化学成分 提取分离 结构研究 

分 类 号：R284.1[医药卫生—中药学]