小柴胡汤加味联合磷酸奥司他韦颗粒治疗儿童流行性感冒的疗效  

Efficacy of modified Xiaochaihu decoction combined with oseltamivir phosphate granules in the treatment of influenza in children

作　　者：黄剑 郑枫[1] 陈茜 HUANG Jian;ZHENG Feng;CHEN Qian(Department of Pediatrics,Taizhou Hospital of Traditional Chinese Medicine,Taizhou,Zhejiang 318000,China)

机构地区：[1]台州市中医院儿科,浙江台州318000

出　　处：《现代医药卫生》2023年第4期599-601,604,共4页Journal of Modern Medicine & Health

基　　金：台州市科学技术局科技计划项目(XM20190175)。

摘　　要：目的 探讨小柴胡汤加味联合磷酸奥司他韦颗粒治疗儿童流行性感冒(流感)的疗效。方法 选取该院2020年5月至2021年5月收治的130例流感儿童为研究对象,按随机数字表法将其分为对照组和治疗组,每组65例。对照组患儿仅给予磷酸奥司他韦颗粒,治疗组在对照组基础上给予小柴胡汤加味治疗。2组连续治疗1周。比较2组症状体征消失时间、血常规指标、临床疗效、血清白细胞介素-6(IL-6)和肿瘤坏死因子α(TNF-α)水平、不良反应发生情况。结果 治疗组患儿发热、咳嗽、咽痛、疲劳消失时间明显短于对照组,差异有统计学意义(P<0.01)。治疗后,2组白细胞、淋巴细胞数明显减少,且治疗组明显少于对照组,差异均有统计学意义(P<0.01)。治疗组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,2组血清IL-6和TNF-α水平显著下降,且治疗组明显低于对照组,差异均有统计学意义(P<0.01)。治疗组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论 小柴胡汤加味联合磷酸奥司他韦颗粒治疗儿童流感疗效明显,能促进患儿症状体征的改善,抑制炎症反应。Objective To investigate the efficacy of modified Xiaochaihu decoction combined with oseltamivir phosphate granules in the treatment of influenza in children.Methods A total of 130 influenza children admitted to this hospital from May 2020 to May 2021 were selected as the study objects, and were divided into the control group and the treatment group according to random number table method, with 65 cases in each group.The control group was treated with oseltamivir phosphate granules, and the treatment group was treated with modified Xiaochaihu decoction on the basis of the control group.The two groups were treated continuously for one week.The disappearance time of symptoms and signs, blood routine indexes, clinical efficacy, serum levels of interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α),and adverse reaction were compared between the two groups.Results The disappearance time of fever, cough, sore throat and fatigue in the treatment group was significantly shorter than that in the control group, and the differences was statistically significant(P<0.01).After treatment, the white blood cell count and lymphocyte count of the two groups were significantly reduced, and the treatment group was significantly less than the control group, the differences were statistically significant(P<0.01).The total effective rate of the treatment group was significantly higher than that of the control group, the difference was statistically significant(P<0.05).After treatment, the serum levels of IL-6 and TNF-α in the two groups were significantly decreased, and the treatment group was significantly lower than the control group, the differences were statistically significant(P<0.01).The incidence of adverse reaction in the treatment group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05).Conclusion The efficacy of modified Xiaochaihu decoction combined with oseltamivir phosphate granules in treating influenza children is significant.It can promote the improvement

关 键 词：小柴胡汤 磷酸奥司他韦颗粒 流行性感冒 白细胞介素-6 肿瘤坏死因子Α 

分 类 号：R72[医药卫生—儿科]