PACAP作用于神经胶质瘤的研究进展  

Research progress of PACAP on glioma

作　　者：陈丹丹(综述)[1] 刘娟娟[1] 李丽(审校) CHEN Dandan;LIU Juanjuan;LI Li(Department of Medicine,Shandong College of Traditional Chinese Medicine,Yantai,Shandong 264100,China)

机构地区：[1]山东中医药高等专科学校医学系,山东烟台264100

出　　处：《现代医药卫生》2023年第4期642-646,共5页Journal of Modern Medicine & Health

基　　金：山东省医药卫生科技发展计划项目(2019WS585);山东省中医药科技项目(Z-2022053)。

摘　　要：垂体腺苷酸环化酶激活多肽(PACAP)是一种存在于体内的神经肽,参与包括cAMP/PKA/CREB、PI3K/Akt等信号通路的调节。神经胶质瘤是发生于中枢神经系统的原发性肿瘤,PACAP在调节部分胶质瘤细胞的增殖、侵袭和迁移过程中发挥重要作用。该文就PACAP作用于胶质瘤细胞的相关机制做一综述。Pituitary adenylate cyclase activating polypeptide(PACAP) is a neuropeptide that exists in the body and participates in the regulation of cyclic adenosine monophosphate(cAMP)/protein kinase A(PKA)/cAMP-response element binding protein(CREB),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt) and other signal pathways.Glioma is a primary tumor occurring in the central nervous system.PACAP plays key roles in regulating the proliferation, invasion and migration of some glioma cells.This review summarized the research progress in the mechanism of PACAP on glioma cells.

关 键 词：垂体腺苷酸环化酶激活多肽 神经胶质瘤 肿瘤微环境 机制 综述 

分 类 号：R34[医药卫生—基础医学]