颅内动脉瘤患者介入栓塞术后血清CYFRA21-1、NSE及VEGF水平与预后的关系研究  

Relationship between CYFRA21-1,NSE and VEGF levels and prognosis in patients with intracranial aneurysm after interventional embolization

作　　者：韩惠 任祖东[1] 周夏[1] 戴荣权[1] HAN Hui(Department of Neurosurgery,Maanshan People's Hospital,Maanshan 243000,China)

机构地区：[1]马鞍山市人民医院神经外科,安徽马鞍山243000

出　　处：《牡丹江医学院学报》2023年第1期55-58,102,共5页Journal of Mudanjiang Medical University

摘　　要：目的探讨脑动脉瘤患者介入栓塞术后血清CYFRA21-1、NSE及VEGF水平与预后的关系。方法将本院2020年8月至2022年3月期间收治的蛛网膜下腔出血的81例破裂颅内动脉瘤患者纳入本研究。根据81例患者术后随访3个月时的Glasgow预后评分,将其分为恢复良好组(n=25)、轻度残疾组(n=18)、重度残疾组(n=15)、植物生存组(n=14)、死亡组(n=9)。所有研究对象行介入栓塞术,采用双抗体夹心ABC-ELISA法检测患者术后第7天血清中的CYFRA21-1、神经元特异性烯醇化酶(NSE)、血管内皮细胞生长因子(VEGF)水平。比较各组患者术后第7天血清NSE、CYFRA21-1、VEGF水平。对患者的预后情况分别与血清NSE、CYFRA21-1、VEGF水平进行相关性分析;分析NSE、CYFRA21-1、VEGF对预后严重程度的影响。结果各组间术后7 d时血清NSE、CYFRA21-1、VEGF水平差异显著(P<0.05),预后越差,血清中NSE、CYFRA21-1、VEGF水平越高。恢复良好组血清中NSE、CYFRA21-1、VEGF水平最低,其次为轻度残疾组、重度残疾组、植物生存,死亡组血清中NSE、CYFRA21-1、VEGF水平最高。颅内动脉瘤患者介入栓塞术后第7天的血清NSE、CYFRA21-1、VEGF水平均与预后严重程度呈显著正相关关系(P<0.05)。颅内动脉瘤患者介入栓塞术后血清NSE、CYFRA21-1、VEGF水平均是影响预后严重程度的独立影响因素(P<0.05),回归系数分别为0.702、1.771、0.611。结论CYFRA21-1、NSE、VEGF均是颅内动脉瘤患者介入栓塞术后预后不良的独立危险因素。Objective To investigate the relationship between the expression of CYFRA21-1,neuron specific enolase(NSE)and vascular endothelial cell growth factor(VEGF)and the prognosis in patients with cerebral aneurysm after interventional embolization.Methods 81 patients with ruptured intracranial aneurysm with subarachnoid hemorrhage admitted to our hospital from August 2020 to March 2022 were enrolled in this study.Based on Glasgow outcome score at 3 months after surgery,81 patients were divided into good recovery group(n=25),mild disability group(n=18),severe disability group(n=15),vegetative survival group(n=14),and death group(n=9).In all studies,the levels of CYFRA21-1,NSE and VEGF in serum at day 7 after embolization were measured by double-antibody sandwich ABC-ELISA.The serum levels of NSE,CYFRA21-1 and VEGF were compared among all groups at day 7 after surgery.The correlation between the prognosis and serum NSE,CYFRA21-1 and VEGF levels was analyzed.The effects of NSE,CYFRA21-1 and VEGF on the severity of prognosis were analyzed.Results Serum levels of NSE,CYFRA21-1 and VEGF were significantly different among all groups at day 7 after operation(P<0.05),the worse the prognosis,the higher the serum levels of NSE,CYFRA21-1 and VEGF.The serum levels of NSE,CYFRA21-1 and VEGF were the lowest in the good recovery group,followed by the mild disability group,the severe disability group and plant survival,and the serum levels of NSE,CYFRA21-1 and VEGF were the highest in the death group.The serum levels of NSE,CYFRA21-1 and VEGF at day 7 after embolization were significantly positively correlated with the prognostic severity of patients with intracranial aneurysm(P<0.05).The levels of serum NSE,CYFRA21-1 and VEGF in patients with intracranial aneurysm after interventional embolization were independent factors affecting the prognosis and severity(P<0.05),the regression coefficients were 0.702,1.771 and 0.611,respectively.Conclusion CYFRA21-1,NSE and VEGF are independent risk factors for poor prognosis of patients with intr

关 键 词：颅内动脉瘤 介入栓塞术 CYFRA21-1 神经元特异性烯醇化酶 血管内皮细胞生长因子 

分 类 号：R651.12[医药卫生—外科学]