黄斑区血流密度与糖尿病视网膜病变分期的相关性研究  

Correlation between macular blood flow density and stage of diabetic retinopathy

作　　者：邓宇 接传红[1] 王建伟[1] 宋小花 刘自强 李媛媛 DENG yu;JIE Chuan-hong;WANG Jian-wei;SONG Xiao-hua;LIU Zi-qiang;LI Yuan-yuan(Eye Hospital China Academy of Chinese Medical Science,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,北京100040

出　　处：《海南医学院学报》2023年第3期198-202,209,共6页Journal of Hainan Medical University

基　　金：国家自然科学基金项目面上项目(81874494);北京市自然科学基金面上项目(7182187);首都卫生发展科研专项(2020-2-4182,2020-3-4184);中国中医科学院科技创新项目(CI2021A02604)。

摘　　要：目的:探究糖尿病视网膜病变患者病情发展与OCTA血流密度等指标之间的联系。方法:选取2020年9月~2021年7月就诊于中国中医科学院眼科医院的63例(100眼)诊断为2型糖尿病的患者,其中糖尿病视网膜病变患者44例(72眼),有2型糖尿病而无视网膜病变(NDR)19例(28眼)。所有患者均进行OCTA检查,统计FAZ、PERIM、AI、FD、SVD、DVD等指标。结果:(1)SVD、旁中心凹SVD,DVD、旁中心凹DVD随DR病程的进展逐渐降低,差异均有统计学意义(P=0.000)SVD中心凹、DVD中心凹差异无统计学意义(P>0.05);(2)SVD、旁中心SVD、DVD、旁中心DVD与DR进程相关系数分别为:-0.525,-0.586,-0.323,-0.424(P<0.05),均呈中等负相关;(3)AI、FD随DR病程进展逐渐降低,差异具有统计学意义(P=0.011,P=0.000),FAZ与PERIM随DR病程变化差异无统计学意义(P>0.05);(4)FAZ、PERIM与DR进程相关系数分别为:-0.031,0.084(P>0.05),无相关性,AI、FD与DR进程相关系数分别为0.307,-0.459(P<0.05),分别呈中等正、负相关;(5)FAZ、PERIM、AI、FD与年龄相关系数分别为:-0.124,-0.052,0.113,-0.170(P>0.05),无相关性。结论:DR病情的进展与OCTA浅层血流密度、深层血流密度有呈中等相关性;与AI、FD呈中等相关性。OCTA可以辅助评估DR疾病进展。Objective:To investigate the association between the development of diabetic retinopathy and OCTA blood flow density.Methods:A total of 63 patients(100 eyes)diagnosed with type 2 diabetes in Eye Hospital of China Academy of Chinese Medical Sciences from September 2020 to July 2021 were selected,including 44 patients(72 eyes)with diabetic retinopathy and 19 patients(28 eyes)with type 2 diabetes without retinopathy(NDR).All patients underwent OCTA examination,and FAZ,PERIM,AI,FD,SVD,DVD and other indicators were counted.Results:(1)SVD,parafoveal SVD,DVD and parafoveal DVD gradually decreased with the progression of DR(P=0.000).There was no significant difference in SVD and DVD fovea(P>0.05).(2)The correlation coefficients between SVD,SVD,DVD,DVD and DR process were-0.525,-0.586,-0.323,-0.424,respectively(P<0.05),and all showed moderate negative correlation.(3)AI and FD gradually decreased with the progression of DR,and the differences were statistically significant(P=0.011,P=0.000),while FAZ and PERIM showed no significant difference with the progression of DR(P>0.05).(4)The correlation coefficients of FAZ,PERIM and DR progression were:-0.031,0.084(P>0.05),no correlation,AI,FD and DR process correlation coefficient were 0.307,-0.459(P<0.05),respectively,were moderately positive and negative correlation;(5)The correlation coefficients of FAZ,PERIM,AI,FD and age were-0.124,-0.052,0.113,-0.170(P>0.05),respectively.Conclusion:There is a moderate correlation between the progression of DR and the superficial and deep blood flow density of OCTA.It was moderately correlated with AI and FD.OCTA can assist in the assessment of DR disease progression.

关 键 词：糖尿病视网膜病变 光学相干断层扫描血管成像 血流密度 相关性分析 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]