开滦研究人群全血铁与臂踝动脉脉搏波传导速度的关系  

The relationship between whole blood iron and brachial ankle pulse wave velocity in Kailuan Study population

作　　者：王洁蕊 何滨[1] 吴寿岭 崔刘福[2] 张艳淑[1] WANG Jie-rui;HE Bin;WU Shou-ling;CUI Liu-fu;ZHANG Yan-shu(Graduate School,North China University of Science and Technology,Tangshan Hebei 063210,China;Department of Rheumatology and Immunology,Tangshan Hebei 063210,China;Department of Cardiology,Kailuan General Hospital,Tangshan Hebei 063210,China)

机构地区：[1]华北理工大学公共卫生学院,河北唐山063210 [2]开滦总医院风湿免疫科,河北唐山063210 [3]开滦总医院心内科,河北唐山063210

出　　处：《中华高血压杂志》2022年第12期1168-1176,共9页Chinese Journal of Hypertension

基　　金：国家自然科学基金(82073598);河北省自然科学基金(H2020209250)。

摘　　要：目的 探讨开滦研究男性和女性人群全血铁水平与臂踝动脉脉搏波传导速度(baPWV)的相关性。方法 采用横断面研究,以参加2016—2017年开滦总医院及林西医院健康体检且进行全血铁及baPWV检测的开滦集团在职和离退休职工2 135人作为观察对象。将不同性别人群全血铁按三分位数分为3组。采用多因素线性回归模型及多因素logistic回归模型分析不同性别人群全血铁对baPWV增加的影响。结果 男性人群中,全血铁低、中、高三分位组baPWV分别为(1 497.2±279.8)、(1 507.0±305.2)、(1 606.5±361.1)cm/s(χ^(2)=16.04,P<0.01)。女性人群中,全血铁低、中、高三分位组baPWV分别为(1 327.4±309.1)、(1 359.3±281.8)、(1 490.2±369.8)cm/s(χ^(2)=19.36,P<0.01)。多因素线性回归分析显示:男性人群中,校正了其他混杂因素后,全血铁每增加1个标准差,baPWV上升32.04 cm/s(P<0.01);女性人群中,校正了其他混杂因素后,全血铁与baPWV相关性无统计学意义。多因素logistic回归分析显示:男性人群中,与全血铁低分位组相比,高分位组发生baPWV≥1 400 cm/s的OR值(95%CI)为1.598(1.171~2.182);女性人群中,与全血铁低分位组相比,高分位组发生baPWV≥1 400 cm/s的OR值(95%CI)为1.619(0.995~2.645)。在敏感性分析中,男性人群中,与全血铁低分位组相比,高分位组发生baPWV>1 800 cm/s的OR值(95%CI)为2.713(1.776~4.144)。结论 高全血铁与开滦研究男性人群baPWV增加相关。Objective To investigate the relationship between whole blood iron level and brachial-ankle pulse wave velocity(baPWV) in males and females from Kailuan Study. Methods A cross-sectional study was conducted among 2 135 employees and retirees of Kailuan Group who took part in the physical examination in Kailuan General Hospital and Linxi Hospital from 2016 to 2017 and were tested for whole blood iron and baPWV. The males and females were divided into three groups according to the tertile of whole blood iron. Multivariate linear regression model and multivariate logistic regression model were used to analyze the effect of whole blood iron on increase of baPWV in different gender groups. Results In the male population, the baPWV of the low, middle and high tertile of whole blood iron groups were(1 497.2±279.8),(1 507.0±305.2) and(1 606.5±361.1) cm/s, respectively(χ^(2)=16.04, P<0.01), while in the female population, which were(1 327.4±309.1),(1 359.03±281.8) and(1 490.2±369.8) cm/s, respectively(χ^(2)=19.36, P<0.01). Multivariate linear regression analysis showed that in the male population, after adjusting for other confounding factors, baPWV increased by 32.04 cm/s(P<0.01) for every 1 standard deviation increase in whole blood iron, while in the female population, the correlation between whole blood iron and baPWV was not statistically significant after adjusting for other confounding factors. In the multivariate logistic regression analysis, after adjusting for other factors, the OR value(95%CI) of baPWV≥1 400 cm/s in the high tertile group was 1.598(1.171-2.182)(P<0.01) compared with the low tertile group in males, while which was 1.619(0.995-2.645) in females. In sensitivity analysis, compared with the low tertile group, the OR value(95%CI) of baPWV>1 800 cm/s in the high tertile group was 2.713(1.776-4.144)(P<0.01). Conclusions High whole blood iron is associated with the increase of baPWV in males from the Kailuan Study.

关 键 词：全血铁 臂踝动脉脉搏波传导速度 动脉硬化 开滦研究 

分 类 号：R54[医药卫生—心血管疾病]