化痰祛瘀方联合西医常规疗法治疗不稳定型心绞痛痰瘀互结证43例临床观察  

Clinical observation of 43 cases of unstable angina pectoris with phlegm and blood stasis binding syndrometreated byHuatanQuyuFang(化痰祛瘀方)combined with conventional Western medicine

作　　者：吕莎莎 姬同超 LYU Shasha;JI Tongchao(Department of TCM Internal Medicine,Nanyang ZHANG Zhongjing Hospital,Nanyang,Henan,473000,China)

机构地区：[1]南阳张仲景医院中医内科,河南南阳473000

出　　处：《甘肃中医药大学学报》2022年第6期44-48,共5页Journal of Gansu University of Chinese Medicine

摘　　要：目的观察化痰祛瘀方联合西医常规疗法治疗不稳定型心绞痛(UAP)痰瘀互结证的临床疗效。方法将86例UAP痰瘀互结证患者采用随机数字表法分为对照组和治疗组,各43例。对照组采用西医常规治疗,治疗组在对照组治疗方法的基础上采用化痰祛瘀方治疗。连续治疗4周后,比较2组的临床疗效,以及治疗前后心绞痛发作情况(发作次数、持续时间),血液流变学指标(血浆黏度、全血高切黏度),血清氧化应激指标[一氧化氮(NO)、丙二醛(MDA)],血清内源性配体-13(Apelin-13)、肥胖抑制素(Obestatin)水平。结果治疗后2组心绞痛发作次数明显减少,持续时间明显缩短,血浆黏度、全血高切黏度及血清MDA、Apelin-13、Obestatin水平均明显降低,血清NO水平明显升高,与同组治疗前比较差异均有统计学意义(P<0.01),且治疗组对各项指标的改善作用更明显,与对照组治疗后比较差异均有统计学意义(P<0.01);对照组总有效率为76.74%(33/43),治疗组为93.02%(40/43),2组比较差异有统计学意义(P<0.05)。结论化痰祛瘀方联合西医常规疗法治疗UAP痰瘀互结证临床疗效显著,能明显缓解心绞痛发作,改善血液流变学,减轻氧化应激反应,调节Apelin-13、Obestatin水平。ObjectiveTo observe the clinical efficacy of Huatan Quyu Fang(化痰祛瘀方)combined with conventional Western medicine in the treatment of unstable angina pectoris(UAP)with phlegm and blood stasis binding syndrome.Methods 86 patients with UAP of phlegm and blood stasis binding syndrome were divided into a control group and a treatment group in a random number table method,with 43 cases in each group.The control group was treated with conventional Western medicine,and the treatment group was treated with Huatan Quyu Fang on the basis of the treatment method of the control group.After 4 weeks of continuous treatment,the clinical efficacy of the two groups were compared,as well as the angina attacks(atack frequency and duration),hemorheology indexes(plasma viscosity,whole blood high tangential viscosity),serum oxidative stress indexes[nitric oxide(NO),malondialdehyde(MDA)J,endogenous ligand-13(Apelin-13)and Obestatin levels before and after treatment.ResultsAfter treatment,the frequency and duration of angina attacks in 2 groups were significantly reduced,plasma viscosity,whole blood high tangential viscosity,serum MDA,Apelin-13 and Obestatin levels were significantly decreased,and serum NO levels were significantly increased in 2 groups,which had statistical significance compared with before treatment(P<0.01).The improvement of various indexes in the treatment group was more obvious,and the difference was statistically significant compared with the control group after treatment(P<0.01).The total effective rate was 76.74%(33/43)in the control group and 93.02%(40/43)in the treatment group,the difference between the two groups was statistically significant(P<0.05).Conclusion Huatan Quyu Fang combined with conventional Western medicine has obvious curative effect on UAP,which can relieve angina pectoris,improve hemorheology,reduce oxidative stress and regulate Apelin-13 and Obestatin levels.

关 键 词：不稳定型心绞痛 痰瘀互结证 化痰祛瘀方 血液流变学 氧化应激指标 内源性配体-13 肥胖抑制素 临床疗效 

分 类 号：R256.22[医药卫生—中医内科学]