A Pd_(2)L_(4) Metallacage-Cored Supramolecular Amphiphile and Its Application in Dual-Responsive Controllable Release  

作　　者：Yongping Chai Peng Qin Xupeng Li Tai-Bao Wei Qi Lin You-Ming Zhang Hong Yao Wen-Juan Qu Bingbing Shi 

机构地区：[1]Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education,Key Laboratory of Eco-environmental Polymer Materials of Gansu Province,College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou,Gansu,730070 China [2]Gansu Natural Energy Research Institute,Lanzhou,Gansu,730046 China

出　　处：《Chinese Journal of Chemistry》2022年第20期2421-2427,共7页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(22001214,21662031,21661028,22061039);B.S.thanks the Natural Science Foundation of Northwest Normal University(NWNU-LKQN2020-02)for financial support.

摘　　要：The construction of multi-responsive supramolecular systems for drug delivery is a challenging task.In this work,a Pd_(2)L_(4) metallacage 1·([BF_(4)]^(−))_(4) with four pyrene units was first designed and synthesized through coordination-driven self-assembly.After the introduction ofγ-CD,a supramolecular amphiphile 1–γ-CD was successfully constructed based on the host–guest molecular recognition betweenγ-CD and the pyrene unit of 1·([BF_(4)]^(−))_(4),which further self-assembled into dual-responsive supramolecular vesicles in aqueous solution.DOX·HCl was used as a model molecule to study the drug encapsulation and release behavior of the supramolecular vesicles.By adjusting the pH of the solution to acidic condition or adding a certain amount ofα-amylase,the vesicle structure was destroyed to achieve rapid and effective release of the drug molecules.This study provides an example for the rational design of efficient dual-responsive supramolecular nanocarriers,which have potential application value in the field of controlled drug delivery.

关 键 词：SELF-ASSEMBLY Molecular recognition Metallacages Host-Guest systems Controllable release 

分 类 号：O6[理学—化学]