Co-delivery of Cisplatin and Chlorin e6 by Poly(phosphotyrosine)for Synergistic Chemotherapy and Photodynamic Therapy  

作　　者：Haisen Zhou Yaoyi Wang Yingqin Hou Zhengkui Zhang Qi Wang Xiaodong Tian Hua Lu 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,Center for Soft Matter Science and Engineering,Key Laboratory of Polymer Chemistry and Physics of Ministry of Education,College of Chemistry and Molecular Engineering,Peking University,Beijing,100871 China [2]Department of General Surgery,Peking University First Hospital,Beijing,100034 China

出　　处：《Chinese Journal of Chemistry》2022年第20期2428-2436,共9页中国化学（英文版）

基　　金：supported by the National Key Research and Development Program of China(2016YFA0201400);the Na-tional Natural Science Foundation of China for Distinguished Young Investigators(22125101).

摘　　要：Nanoscale drug delivery systems(NDDSs)have emerged as promising carriers for combinational therapy by co-delivery of multiple drugs and modalities.However,most co-delivery systems require the use of complicated materials and formulations.Herein,we report the single use of a polymeric material,namely mPEG-block-poly(phosphotyrosine)(mPEG-b-PpY),as a multi-functional carrier for the facile fabrication of NDDS Pt/Ce6@mPEG-b-PpY(PtCeNP)for the co-delivery of cisplatin and photosensitizer chlorin e6(Ce6)via phosphato-platinum coordination andπ-πstacking,respectively.PtCeNP improves the solubility,cellular uptake,and bioavailability of both parental drugs,and showed strong synergistic antitumor efficacy both in vitro and in vivo through combined chemo-photodynamic therapy.Our results indicate that PpY is a biocompatible,multifunctional,and promising carrier material suitable for a variety of drugs and may simplify the design for co-delivery systems.

关 键 词：Drug delivery Poly(phosphotyrosine) Block copolymers Nanoparticles Combinational chemo-photodynamic therapy 

分 类 号：O65[理学—分析化学]