Synthesis and Evaluation of Photophysical Properties of C-3 Halogenated Derivatives of 2-Phenylimidazo[1,2-a]pyridine  

作　　者：Hong Chen Yanyan Wang Qingjie Liu Yanchun Guo Shuxia Cao Yufen Zhao 

机构地区：[1]College of Chemistry,Zhengzhou University,Zhengzhou,Henan,450001 China [2]Institute of Drug Discovery Technology,Ningbo University,Ningbo,Zhejiang,315211 China

出　　处：《Chinese Journal of Chemistry》2022年第19期2313-2328,共16页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(No.21105091)for financial support.

摘　　要：A CuX-mediated regioselective halogenation reaction of 2-phenylimidazo[1,2-a]pyridine in the presence of oxygen is introduced in this paper.This reaction provides an effective method for the production of C-3 halogenated 2-phenylimidazo[1,2-a]pyridines with a yield of up to 96%.A plausible mechanism for the formation of title compounds via 2-phenylimidazo[1,2-a]pyridine–CuX complex intermediate is proposed.The structure of representative compounds is established by the single crystal XRD method.The electronic structure,corroborated by Hirshfeld surface analysis and DFT calculations,rationalizes characters of relevant absorptions and emission as well as large Stokes shifts.

关 键 词：Imidazole[1 2-a]lpyridine HALOGENATION Cuprous halide DFT calculations Photophysical properties 

分 类 号：O62[理学—有机化学]