散斑血流灌注成像在医学中的应用  

Application of Speckle Perfusion Imaging in Medicine

作　　者：张进勇 谢宗能 孔平[1,2] 李玥 Zhang Jinyong;Xie Zongneng;Kong Ping;Li Yue(School of Health Science and Engineering,University of Shanghai for Science&Technology,Shanghai 200093,China;Shanghai Key Laboratory of Molecular Imaging,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]上海健康医学院上海市分子影像学重点实验室,上海201318

出　　处：《激光与光电子学进展》2022年第22期43-54,共12页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(81603142,81830052);上海市教育委员会“教师专业发展工程”(A3-2601-20-311001-24);上海市科学技术委员会“上海市分子影像学重点实验室建设项目”(18DZ2260400)。

摘　　要：散斑血流灌注成像是一种利用红细胞对激光的散射特性监测血流灌注信息的医学成像技术。同传统血流灌注监测方法相比,其具有实时显像、分辨率高、成本低、无需造影剂等优点,尤其在体表血流监测方面独具优势。简述了散斑血流灌注成像的基本原理,总结了其技术进展及在眼底血流、脑血流、体表微循环监测及肿瘤血流灌注监测几个方面的应用,并介绍了其在监测鸡胚肿瘤血管新生方面的新应用。Speckle blood perfusion imaging is a medical imaging technique that monitors blood perfusion information based on the scattering characteristics of red blood cells to the laser.Its benefits over traditional blood perfusion monitoring technologies include real-time imaging,high resolution,cheap cost,and the absence of contrast chemicals,particularly in surface blood flow monitoring.This review focuses on the basic principle of speckle blood perfusion imaging,technical advancements,and its application in monitoring fundus blood flow,cerebral blood flow,body surface microcirculation,and tumor blood perfusion,as well as its new application in monitoring angiogenesis of chicken embryo tumors.

关 键 词：散斑成像 医学光学诊断 血流成像 实时监测 

分 类 号：O436[机械工程—光学工程]