孕14周应用HARRT治疗HIV感染孕妇的效果  

Effect of HARRT on HIV Infected Pregnant Women at 14 Weeks of Pregnancy

作　　者：廖蔼怡 LIAO Aiyi(Department of Obstetrics,Panyu Maternal and Child Health Hospital,Guangzhou,Guangdong,511400)

机构地区：[1]广州市番禺区妇幼保健院产科,广东广州511400

出　　处：《智慧健康》2022年第35期51-54,共4页Smart Healthcare

基　　金：番禺区科技计划项目“HIV母婴阻断综合措施及效果评价”(项目编号:2021-Z04-100)。

摘　　要：目的探讨孕14周应用高效抗逆转录病毒疗法(HARRT)治疗艾滋病病毒(HIV)感染孕妇的效果。方法以本院2015年1月-2020年12月收治的55例HIV感染孕妇作为研究对象,按照随机数字表法分为两组,两组均接受HARRT疗法治疗,对照组27例在孕14周后接受治疗,观察组28例在孕14周接受治疗,观察两组患者HIV病毒载量变化情况、CD4^(+)T淋巴细胞变化情况以及分娩结局。结果治疗前,两组HIV病毒载量<50copies/mL患者总数均为0例,产前1个月以及产后三个月两组HIV病毒载量<50copies/mL患者总数均较治疗前上升,但组间对比差异无统计学意义(P>0.05);治疗前,两组CD4^(+)T淋巴细胞水平对比差异无统计学意义(P>0.05),产前1个月以及产后三个月两组均较治疗前上升且观察组高于对照组,同时观察组CD4^(+)T淋巴细胞较治疗前升高程度>30%例数多于对照组(P<0.05);两组患者母亲结局以及新生儿结局对比均差异无统计学意义(P>0.05)。结论在孕14周以及孕28周运用HARRT均可阻断HIV病毒,但是孕14周运用该方案更有助于孕妇建立免疫功能,且不影响母婴结局。Objective To investigate the effect of highly active antiretroviral therapy(HARRT)on pregnant women infected with HIV(HIV)for 14 weeks.Methods 55 pregnant women with HIV infection treated in our hospital from January 2015 to December 2020 were divided into two groups according to the random number table method.Both groups were treated with HARRT therapy,27 cases in the control group were treated after 14 weeks of gestation,and 28 cases in the observation group were treated at 14 weeks of gestation.The changes of HIV viral load in the two groups were observed changes of CD4^(+)T lymphocytes and delivery outcome.Results Before treatment,the total number of patients with HIV viral load<50 copies/ml in the two groups was 0.The total number of patients with HIV viral load<50 copies/mL in the two groups increased one month before delivery and three months after delivery,but there was no significant difference between the two groups(P>0.05);Before treatment,there was no significant difference in the levels of CD4^(+)T lymphocytes between the two groups(P>0.05).The levels of CD4^(+)Tlymphocytes in the two groups increased one month before treatment and three months after delivery,and the levels of CD4^(+)T lymphocytes in the observation group were higher than those in the control group.At the same time,the number of CD4^(+)T lymphocytes in the observation group was higher than that in the control group(P<0.05);There was no significant difference in maternal outcome and neonatal outcome between the two groups(P>0.05).Conclusion The use of HARRT at 14 and 28 weeks of pregnancy can block HIV virus,but the use of HARRT at 14 weeks of pregnancy is more helpful for pregnant women to establish immune function,and does not affect the outcome of mother and baby.

关 键 词：艾滋病病毒 高效抗逆转录病毒疗法 HIV病毒载量 分娩结局 

分 类 号：R714.251[医药卫生—妇产科学]