百令胶囊辅助缬沙坦治疗IgA肾病及对肾功能、Th1/Th2漂移、尿PCX、B7-1水平的影响  

Effects of Bailing capsules assisting valsartan in the treatment of IgA nephropathy and its influence on renal function,Th1/Th2 drift,urine PCX and B7-1 levels

作　　者：罗丽 刘中奇 范予劼 LUO Li;LIU Zhongqi;FAN Yujie(Department of Nephrology,Western Theatre Command General Hospital,Chengdu 610083,China;Third Department of Outpatient,Western Theatre Command General Hospital,Chengdu 610083,China)

机构地区：[1]西部战区总医院肾内科,成都610083 [2]西部战区总医院第三派驻门诊部,成都610083

出　　处：《广州医药》2023年第2期46-49,60,共5页Guangzhou Medical Journal

摘　　要：目的观察百令胶囊辅助缬沙坦治疗IgA肾病效果及对患者肾功能、细胞免疫调节、尿足细胞标志蛋白的影响。方法选取2019年5月—2021年5月西部战区总医院肾内科收治经肾活检确诊为IgA肾病,筛选治疗方案中尚未使用激素及免疫抑制剂的80例患者,按住院先后顺序随机分为观察组和对照组,每组各40例。对照组给予缬沙坦治疗,观察组给予百令胶囊辅助缬沙坦治疗,治疗12周后,比较2组的疗效、治疗前后肾功能指标[24 h蛋白尿(24 h Upro)、尿素氮(BUN)、血肌酐(SCr)、尿红细胞(RBC)计数]、1型/2型辅助性T细胞(Th1/Th2)代表细胞因子[γ-干扰素(IFN-γ)、白介素-4(IL-4)]、尿足细胞标志蛋白[尿足萼糖蛋白(PCX)、尿足细胞B7-1分子(B7-1)]水平。结果治疗12周后,观察组的治疗总有效率为95.0%,高于对照组的82.5%;观察组的24 h Upro、BUN、SCr、尿RBC计数低于对照组,IFN-γ、Th1/Th2低于对照组、IL-4高于对照组,尿PCX、B7-1水平低于对照组;差异均有统计学意义(P<0.05)。结论百令胶囊辅助缬沙坦治疗IgA肾病患者,可以提高临床疗效,有效保护患者肾功能,调节其免疫状态,减轻肾损伤。Objective To observe the effects of Bailing capsules assisting valsartan in the treatment of IgA nephropathy and its influence on renal function,cellular immune regulation and urine prodocytes marker protein.Methods From May 2019 to May 2021,80 patients with IgA nephropathy confirmed by renal biopsy in the Nephrology Department of Western Theatre Command General Hospital,who had not used hormones or immunosuppressants in the treatment were selected.Patients were divided into observation group and control group according to the order of hospitalization,40 cases in each group.The control group was given valsartan,and the observation group was given Bailing capsules and valsartan.After 12 weeks of treatment,the efficacy,the levels of renal function indexes[24 h proteinuria(24 h Upro),urea nitrogen(BUN),serum creatinine(SCr),urinary red blood cell(RBC)count],type 1/type 2 helper T cells(Th1/Th2)represent cytokines[interferon-γ(IFN-γ),interleukin-4(IL-4)],urine prodocytes marker protein[urine podocalyxin(PCX),urinary podocyte B7-1 molecule(B7-1)]before and after treatment were compared between the two groups.Results After treatment,the total effective rate in observation group was higher than that in control group(95.0%vs 82.5%).The 24 h Upro,BUN,SCr levels and urine RBC count in observation group were lower than those in control group,IFN-γand Th1/Th2 levels were lower than those in control group,the IL-4 level was higher than that in control group,and the levels of urine PCX and B7-1 were lower than those in control group.Those differences were statistically significant(P<0.05).Conclusions Bailing capsules assisting valsartan in the treatment of IgA nephropathy can improve clinical efficacy,effectively protect the renal function of patients,regulate the immune status,and alleviate renal injury.

关 键 词：IGA肾病 百令胶囊 缬沙坦 肾功能 

分 类 号：R692.31[医药卫生—泌尿科学]