十二指肠黏膜微生态与乙肝相关慢加急性肝衰竭的相关性的研究进展  

Progress in understanding of relationship between duodenal mucosal microecology and hepatitis B virus related acute-on-chronic liver failure

作　　者：李世炼 郑少琴 汤影子 刘慧敏 毛青 Shi-Lian Li;Shao-Qin Zheng;Ying-Zi Tang;Hui-Min Liu;Qing Mao(Department of Infectious Diseases,Southwest Hospital,Army Medical University,Chongqing Key Laboratory of Infectious Disease Research,Chongqing 400038,China)

机构地区：[1]陆军军医大学西南医院全军感染病研究所,重庆市感染病研究重点实验室,重庆市400038

出　　处：《世界华人消化杂志》2022年第24期1074-1078,共5页World Chinese Journal of Digestology

基　　金：国家科技重大专项,No.2017ZX10203201-006;国家科技重大专项,No.2017ZX10202201-00-010;重庆市自然科学基金,No.cstc2017jcyjAX0398。

摘　　要：据统计,全国范围内乙型肝炎病毒(hepatitis B virus,HBV)感染率仍高,发生慢加急性肝衰竭(acute-onchronic liver failure,ACLF)病死率高.近年,针对慢性乙型肝炎相关的慢加急性肝衰竭(hepatitis B virus related acute-on-chronic liver failure,HBV-ACLF)粪便菌群的研究结果发现,肠道微生态影响着HBV-ACLF的发生、发展及转归.但粪便菌群不能完全替代整个肠道微生态,十二指肠黏膜微生态研究或许是一个新方向.本文将从机制、生理、解剖特点方面,对十二指肠黏膜菌群关于HBV-ACLF临床转归的影响作一综述.According to statistics,the rate of hepatitis B virus(HBV)infection is still high in China,and the mortality of acuteon-chronic liver failure(ACLF)is also high.In recent years,studies on the fecal flora of patients with HBV related ACLF have found that intestinal microecology affects the occurrence,development,and prognosis of HBV related ACLF.However,fecal flora cannot completely replace the whole intestinal microecology,and duodenal mucosal microecology may be a new research direction.This review discusses the influence of duodenal mucosal flora on the clinical outcome of HBV-ACLF with regard to mechanism,physiology,and anatomical characteristics.

关 键 词：乙型肝炎病毒 慢加急性肝衰竭 十二指肠黏膜菌群 肠道菌群 综述 

分 类 号：R512.62[医药卫生—内科学] R575.3[医药卫生—临床医学]