心房颤动病人IL-1β、Calpain-2水平与心脏结构重构的相关性研究  

Relationship between IL-1β,Calpain-2 levels and cardiac structure in patients with atrial fibrillation

作　　者：卢园园 李浩宇 耿嘉逸 雷思思 刘晨阳 康品方[1] 张宁汝[1] LU Yuan-yuan;LI Hao-yu;GENG Jia-yi;LEI Si-si;LIU Chen-yang;KANG Pin-fang;ZHANG Ning-ru(Department of Cardiology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004;Cardiovascular and Cerebrovascular Disease Research Center,Bengbu Medical College,Bengbu Anhui 233030;Clinical Medical College,Anhui Medical University,Hefei Anhui 230000,China;School of Public Health,Bengbu Medical College,Bengbu Anhui 233030)

机构地区：[1]蚌埠医学院第一附属医院心血管内科,安徽蚌埠233004 [2]蚌埠医学院心脑血管病研究中心,安徽蚌埠233030 [3]安徽医科大学临床医学院,安徽合肥230000 [4]蚌埠医学院公共卫生学院,安徽蚌埠233030

出　　处：《蚌埠医学院学报》2023年第1期95-99,共5页Journal of Bengbu Medical College

基　　金：国家自然科学基金资助项目(81970313);安徽省重点研究和开发计划(1804h08020246);蚌埠医学院第一附属医院优秀青年科学基金项目(2019byyfyyq04);蚌埠医学院研究生创新计划(Byycx20079)。

摘　　要：目的:探讨心房颤动(房颤)病人血清中白细胞介素-1β(IL-1β)、钙蛋白酶-2(Calpain-2)表达水平及与心脏结构重构的相关性。方法:选取确诊为房颤的病人150例为观察组,依据2020年ESC/EACTS房颤诊断和管理指南将其分为非阵发性房颤组和阵发性房颤组;选取同时段健康体检者120名作为对照组。分别检测血清IL-1β、Calpain-2以及超声心动图中左心室舒张期内径(LVDd)、左心房内径(LAD)、左心室射血分数(LVEF)和左心室缩短分数(FS)等指标,比较3组不同指标是否存在差异;运用Pearson相关性分析血清IL-1β、Calpain-2与超声心动图检查结果的相关性;采用二元logistic回归分析,探寻房颤的危险因素。结果:观察组中IL-1β、Calpain-2含量显著高于对照组(P<0.05),而且非阵发性房颤病人明显高于阵发性房颤病人(P<0.05)。在超声心动图指标中非阵发性房颤组LAD、LVDd均高于阵发性房颤组以及对照组(P<0.05),LVEF、FS均低于阵发性房颤组及对照组(P<0.05)。二元logistic回归分析显示IL-1β、Calpain-2是房颤发生的危险因素。Spearman相关性分析显示IL-1β、Calpain-2与LAD、LVDd呈正相关关系(P<0.01),而与LVEF、FS呈显著负相关关系(P<0.01)。结论:IL-1β、Calpain-2与LAD、LVDd呈正相关关系,参与了心脏结构重构过程,进而促进了房颤的发生与发展。Objective:To investigate the relationship between the expression levels of interleukin-1β(IL-1β),calpain-2(Calpain-2)and cardiac remodeling in patients with atrial fibrillation.Methods:A total of 150 patients diagnosed with atrial fibrillation(AF)were selected as the observation group,and divided into non-paroxysmal AF group and paroxysmal AF group according to the 2020 ESC/EACTS GUIDELINES for the diagnosis and Management of AF.A total of 120 healthy subjects at the same period were selected as the control group.Serum IL-1β,Calpain-2 contents,left ventricular diastolic diameter(LVDd),left atrial diameter(LAD),left ventricular ejection fraction(LVEF)and left ventricular shortening fraction(FS)were detected by echocardiography,and the differences among the three groups were compared.Pearson correlation was used to analyze the correlation between serum IL-1βand Calpain-2 contents and the results of echocardiography.Binary logistic regression was used to explore the risk factors of AF.Results:The contents of serum IL-1βand Calpain-2 in the observation group were significantly higher than those in the control group(P<0.05),and those in the patients without paroxysmal AF were significantly higher than those in the patients with paroxysmal AF(P<0.05).The indexes of LAD and LVDd in non-paroxysmal AF group were higher than those in paroxysmal AF group and control group(P<0.05),but LVEF and FS were lower than those in paroxysmal AF group and control group(P<0.05).Spearman correlation analysis showed that IL-1βand Calpain-2 were positively correlated with LAD and LVDd(P<0.01),but negatively correlated with LVEF and FS(P<0.01).Binary logistic regression analysis showed that IL-1βand Calpain-2 were the risk factors for AF.Conclusions:IL-1βand Calpain-2 were positively correlated with LAD and LVDd,and were involved in the process of cardiac remodeling,thus promoting the occurrence and development of atrial fibrillation.

关 键 词：心房颤动 白细胞介素-1Β 钙蛋白酶-2 心脏结构重构 

分 类 号：R541.75[医药卫生—心血管疾病]