黄角汤治疗急性期脑梗死的临床疗效观察  

Application of Huangjiao Decoction(黄角汤)in Treatment of Acute Cerebral Infarction

作　　者：石磊[1] 王新华[1] 陈宁宁[1] SHI Lei;WANG Xinhua;CHEN Ningning(The Third Department of Neurology,Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan,China)

机构地区：[1]郑州大学第五附属医院,河南郑州450000

出　　处：《实用中医内科杂志》2022年第12期67-70,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：河南省医学科技攻关计划项目(20200477)。

摘　　要：目的分析脑梗死急性期患者采取黄角汤治疗的临床效果,以期控制病情,减少死亡。方法选择近三年(2019年1月—2022年1月)90例医院脑梗死急性期患者,其中男女人数分别为44例、46例,发病治溶栓时间均在1~6 h内,并且均符合临床诊治指南标准。按照随机分组对照研究,45例实施常规治疗(对照组),45例在常规治疗的基础上给予黄角汤治疗,分析两组临床疗效(包括神经缺损评分、神经缺损指标变化、血清炎性因子水平变化、并发症及不良反应、生活质量评分)。结果治疗1月后,观察组、对照组患者治疗后神经缺损评分(NIHSS)、神经功能损伤指标变化(血清胶质纤维酸性蛋白(GFAP)、神经元特异性烯醇化酶(NSE)、S100β蛋白)较治疗前有明显改善,且观察组均低于对照组,差异有统计学意义(P<0.05);观察组、对照组患者治疗后炎性水平[肿瘤坏死因子(TNF-α)、白细胞介素-1(IL-1β)、高敏C反应蛋白(hs-CPR)]较治疗前有明显均降低,且观察组低于对照组,差异有统计学意义(P<0.05);随访1个月,观察组、对照组患者生活质量评分(SF-36)均有明显提高,且观察组SF-36评分高于对照组,差异有统计学意义(P<0.05)。结论黄角汤治疗脑梗死急性期患者有显著效果,可进一步降低其血清炎性因子,改善神经缺损症状,疗效安全可靠,同时还能提高其生活质量水平,对促进预后有显著效果,临床应用价值高。Objective To analyze the clinical effect of Huangjiao Decoction(黄角汤)on patients with acute cerebral infarction in order to control the disease and reduce death.Methods Ninety patients with acute cerebral infarction in the hospital in recent three years(January 2019 to January 2022)were selected,including 44 men and 46 and women.The time of thrombolysis was within 1-6 h,and all met the standards of clinical diagnosis and treatment guidelines.According to the randomized controlled study,45 cases were treated with routine treatment(control group),and 45 cases were treated with Huangjiao Decoction on the basis of routine treatment.The clinical effects of the two groups were analyzed(including nerve defect score,nerve defect index change,serum inflammatory factor level change,complications and adverse reactions,quality of life score).Results After one month of treatment,the changes of nerve defect score(NIHSS)and neurological injury indexes[serum glial fibrillary acidic protein(GFAP),neuron specific enolase(NSE),S100βprotein]in the observation group and the control group after treatment were significantly improved compared with those before treatment,and those of the observation group were lower than those of the control group(P<0.05).The levels of tumor necrosis factor(TNF-α),interleukin-1(IL-1β)and high sensitivity C-reactive protein(hs-CPR)in the observation group and the control group after treatment were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).After one month of follow-up,the quality of life score(SF-36)of patients in the observation group and the control group were significantly improved,and the SF-36 score of the observation group was significantly higher than that of the control group(P<0.05).Conclusion Huangjiao Decoction has a significant effect on patients with acute cerebral infarction.It can further reduce the serum inflammatory factors and improve the symptoms of nerve defect.The curative effect is safe and reliable.At the same tim

关 键 词：脑梗死 急性期 黄角汤 神经缺损 GFAP/NSE/S100β蛋白 血清炎性因子 生活质量 中医药疗法 临床效果 

分 类 号：R277.7[医药卫生—中医学]