硫酸乙酰肝素蛋白聚糖介导人畜共患病病毒感染机制的研究进展  

Advances in the mechanism of coronavirus infection mediated by heparan sulfate proteoglycans

作　　者：林敏华[1] 丰志华 李兆龙 Lin Minhua;Feng Zhihua;Li Zhaolong(Fujian Key Laboratory of Innate Immune Biology/Biomedical Research Center of South China,Fujian Normal University,Fuzhou 350117;Institute of Animal Husbandry and Veterinary Medicine,Fujian Academy of Agricultural Sciences,Fuzhou 350013)

机构地区：[1]福建省天然免疫生物学重点实验室/福建师范大学南方生物医学研究中心,福州350117 [2]福建省农业科学院畜牧兽医研究所,福州350013

出　　处：《福建畜牧兽医》2023年第1期24-27,共4页Fujian Journal of Animal Husbandry and Veterinary medicine

摘　　要：硫酸乙酰肝素蛋白聚糖(HSPGs)由多个带负电荷的硫酸乙酰肝素(HS)多糖附着在细胞表面组成。HSPGs通过调控多种信号分子与其受体结合,从而参与并调节体内许多生物反应过程。由于其分布广泛且带负电荷的特性,HSPGs被许多微生物病原体,特别是病毒作为附着在宿主细胞上的辅助因子,成为病毒感染宿主的关键因子。本文简要综述HSPGs与多种人畜共患病病毒的相互作用方式,并重点介绍其作为辅助受体的机制,有望为人畜共患病防治提供一定的理论基础。Heparan sulfate proteoglycans(HSPGs) are composed of multiple negatively charged, heparan sulfate(HS) polysaccharides attached to the cell surface. HSPGs bind to their receptors, thus participating in and regulating many biological response processes in vivo. Due to their widely distributed and negatively charged properties, HSPGs are used by many microbial pathogens, especially viruses, as key cofactors attached to host cells. This paper briefly reviews the way that HSPGs interact with multiple zoonotic viruses,and highlights their mechanisms as accessory receptors, which is expected to provide some theoretical basis for the prevention and treatment of zoonosis.

关 键 词：硫酸乙酰肝素蛋白聚糖(HSPGs) 病毒 病毒受体 

分 类 号：S855.99[农业科学—临床兽医学]