参与CKD-MBD的新因子  

Novel factors involved in chronic kidney disease-mineral and bone disorder(CKD-MBD)

作　　者：郭歆 方敬爱[2] 王蕊花[2] 张晓东[2] 刘文媛[2] 常沁涛[2] GUO Xin;FANG Jing-ai;WANG Rui-hua;ZHANG Xiao-dong;LIU Wen-yuan;CHANG Qin-tao(First Clinical College,Shanxi Medical University,Taiyuan 030001,China;Department of Nephrology,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,太原030001 [2]山西医科大学第一附属医院肾内科,太原030001

出　　处：《中国血液净化》2023年第1期44-47,共4页Chinese Journal of Blood Purification

摘　　要：多种生物因子参与着慢性肾脏病矿物质和骨代谢异常(chronic kidney disease–mineral and bone disorder,CKD-MBD)的发生发展。除了经典的甲状旁腺激素(PTH)/维生素D轴理论,最近有研究发现成纤维细胞生长因子23(fibroblast growth factor23,FGF23)/Klotho、牙基质蛋白1(dentin matrix protein 1,DMP1)、分泌型蛋白Dickkopf-1(secretory protein Dickkopf 1,DKK1)和硬化蛋白(sclerostin)等因子也直接或间接参与着CKD-MBD的进展。本文将对上述因子的最新研究做一综述。Many biological factors are involved in the occurrence and development of chronic kidney disease-mineral and bone disorder(CKD-MBD). In addition to the classic parathyroid hormone(PTH)/vitamin D axis theory, recent studies have found that fibroblast growth factor 23, FGF23/Klotho, dentin matrix protein 1(DMP1), secretory protein DicKKOPF-1(DKK1) and sclerostin are also directly or indirectly involved in the progression of CKD-MBD. This paper reviews the latest research on these factors.

关 键 词：慢性肾脏病矿物质和骨代谢异常 成纤维细胞生长因子23/Klotho 分泌型蛋白Dick-kopf-1 硬化蛋白 牙基质蛋白1 

分 类 号：R692[医药卫生—泌尿科学]