电针镇痛及其与刺激参数的量效关系研究:近三十年研究新进展  

The dose-effect relationship of electroacupuncture analgesia and its stimulus parameters:progress in the last 3 decades

作　　者：梁宜[1,2,3] 周杰[1,2] 孙晶[1,2] 范新政 郑思懿 房军帆[1,2,3] 方剑乔[1,2,3] Yi LIANG;Jie ZHOU;Jing SUN;Xin-zheng FAN;Si-yi ZHENG;Jun-fan FANG;Jian-qiao FANG(Department of Acupuncture and Moxibustion,The Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310005,China;The Third Clinical Medical School of Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310053,China;Department of Neurobiology and Acupuncture Research,Institute of Acupuncture and Moxibustion,Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学附属第三医院针灸科,中国杭州310005 [2]浙江中医药大学第三临床医学院,中国杭州310053 [3]浙江中医药大学针灸神经生物学实验室,针灸研究院,中国杭州310053

出　　处：《World Journal of Acupuncture-Moxibustion》2023年第1期12-19,共8页世界针灸杂志（英文版）

基　　金：Supported by Key Research Projects on the Modernization of TCM,the National Key Research and Development Program of the Ministry of Science and Technology(2018YFC1704600).

摘　　要：In this review,we explored the dose-effect relationship of electroacupuncture(EA)analgesia and its stimulus parameters by searching articles on clinical and experimental research of EA analgesia in the past30 years.The impacts on the analgesic effects are discussed in terms of the pulse waveform,frequency,amplitude,wave width,and time effect,as well as parameter combinations,and the optimization of the EA parameters are summarized for the treatment of neuropathic,inflammatory,and cancer pains.It was initially discovered that the distant-dense(D-D)wave(2/15 Hz or 2/100 Hz)and stimulus for 30-45 min were appropriate in the treatment of chronic inflammatory pain,the strong stimulus was applicable to the acute stage of pain(twice a week),while the weak stimulus was for the stable stage(once weekly).The continuous(2 Hz)/D-D wave(2/100 Hz)and moderate/low intensity of stimulus for 30-45 min are preferred in the treatment of neuropathic pain with EA,once daily or every 2 days.Regarding the treatment of cancer pain,EA with continuous(2 Hz or 100 Hz)or D-D wave(2/100 Hz),moderate and low intensity of stimulus for 30-45 min is adopted,once every 2 days.There is a certain rule for the correlation of each parameter and the combination of parameters to ensure an analgesic effect of EA,which should be further explored in future studies.

关 键 词：Cancer pain Electroacupuncture analgesia Inflammatory pain Neuropathic pain REVIEW Stimulus parameters 

分 类 号：R246.2[医药卫生—针灸推拿学]