Chemerin、VEGF与缺血低灌注区面积间的关系及对短期预后的预测价值  

The relationship between Chemerin,VEGF and ischemic hypoperfusion area and their predictive values for short-term prognosis

作　　者：闫志荣 王帅 王锦梅[2] YAN Zhirong;WANG Shuai;WANG Jinmei(Department of Pharmacy,Kailuan General Hospital,Tangshan,Hebei 063000,China;Department of Rehabilitation,Kailuan General Hospital,Tangshan,Hebei 063000,China)

机构地区：[1]河北省唐山市开滦总医院药剂科,河北唐山063000 [2]河北省唐山市开滦总医院康复科,河北唐山063000

出　　处：《国际检验医学杂志》2023年第4期401-405,411,共6页International Journal of Laboratory Medicine

基　　金：河北省医学科学研究课题项目(20200160)。

摘　　要：目的探讨Chemerin、血管内皮生长因子(VEGF)与缺血低灌注区面积间的关系及对短期预后的预测价值。方法将2018年5月至2021年10月于该院治疗的87例急性脑梗死(ACI)患者纳入研究作为观察组。另外,选取同期于该院体检的87例健康者作为对照组。比较两组基本资料及血清Chemerin、VEGF水平。采用Logistic回归分析ACI的影响因素,Pearson相关分析ACI患者血清Chemerin、VEGF水平与缺血低灌注区面积的相关性,受试者工作特征(ROC)曲线分析血清Chemerin、VEGF对ACI患者短期预后预测价值。结果两组吸烟史、饮酒史、卒中家族史、高血压、糖尿病、高血脂比例及血清Chemerin、VEGF水平比较,差异有统计学意义(P<0.05);Logistic回归分析显示:在控制吸烟史、饮酒史、卒中家族史、高血压、糖尿病、高血脂等因素后,高水平Chemerin、VEGF为ACI独立危险因素(P<0.05);血清Chemerin、VEGF水平与缺血低灌注区面积均呈正相关(r=0.810、0.979,P<0.05);Logistic回归分析显示,缺血低灌注区面积大及高水平Chemerin、VEGF为ACI独立危险因素(P<0.05);ROC曲线分析显示:Chemerin、VEGF联合预测ACI患者短期预后的曲线下面积(0.877)最大,灵敏度为79.31%,特异度为82.76%。结论ACI患者血清Chemerin、VEGF水平与缺血低灌注区面积呈正相关,而且二者联合可有效预测患者短期预后情况,为临床干预提供依据。Objective To investigate the relationship between Chemerin,vascular endothelial growth factor(VEGF)and ischemic hypoperfusion area and their predictive value for short-term prognosis.Methods A total of 87 patients with acute cerebral infarction(ACI)treated in the hospital from May 2018 to October 2021 were enrolled in the study as the observation group.In addition,87 healthy people who underwent physical examination in the hospital during the same period were enrolled as the control group.The basic data and serum levels of Chemerin and VEGF were compared between the two groups.Logistic regression analysis was used to analyze the influencing factors of ACI,Pearson correlation analysis was used to analyze the correlation between serum Chemerin and VEGF levels and the area of ischemic hypoperfusion in ACI patients.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum Chemerin and VEGF for the short-term prognosis of ACI patients.Results There were significant differences in smoking history,drinking history,family history of stroke,proportion of hypertension,diabetes,hyperlipidemia,and serum levels of Chemerin and VEGF between the two groups(P<0.05).Logistic regression analysis showed that after controlling for smoking history,drinking history,family history of stroke,hypertension,diabetes,and hyperlipidemia,high levels of Chemerin and VEGF were independent risk factors for ACI(P<0.05).The serum levels of Chemerin and VEGF were positively correlated with the area of ischemic hypoperfusion(r=0.810,0.979,P<0.05).Logistic regression analysis showed that large area of ischemic hypoperfusion and high levels of Chemerin and VEGF were independent risk factors for ACI(P<0.05).ROC curve analysis showed that the combination of Chemerin and VEGF had the highest area under curve(0.877)for predicting the short-term prognosis of ACI patients,with the sensitivity of 79.31%and specificity of 82.76%.Conclusion The serum levels of Chemerin and VEGF in ACI patients are positively correlated with

关 键 词：急性脑梗死 CHEMERIN 血管内皮生长因子 缺血低灌注区面积 短期预后 

分 类 号：R446.11[医药卫生—诊断学]