cHNSCC患者PD-L1、MMP1表达分析及与术后复发的关系  

Significance of PD-L1 and MMP1 expression in patients with cHNSCC and their correlation with postoperative recurrence

作　　者：靳书滨[1] 刘晓燕 耿文华 焦建军[1] JIN Shubin;LIU Xiaoyan;GENG Wenhua;JIAO Jianjun(Department of Oral and Maxillofacial Surgery,Handan Central Hospital,Handan,Hebei 056001,China)

机构地区：[1]邯郸市中心医院口腔颌面外科,河北邯郸056001

出　　处：《国际检验医学杂志》2023年第4期461-464,471,共5页International Journal of Laboratory Medicine

基　　金：邯郸市科学技术研究与发展计划项目(1823208058ZC)。

摘　　要：目的分析程序性细胞死亡蛋白配体-1(PD-L1)、基质金属蛋白酶1(MMP1)在头颈部皮肤鳞状细胞癌(cHNSCC)患者中的表达情况,探讨其与术后复发的关系。方法将2020年5月至2021年8月该院收治的cHNSCC患者173例纳入研究,检测cHNSCC患者术中切除的肿瘤组织与癌旁组织中PD-L1、MMP1的表达情况。比较不同临床分期cHNSCC患者PD-L1、MMP1表达情况及不同术后复发情况的cHNSCC患者的临床病理资料。分析cHNSCC患者术后复发的影响因素。分析PD-L1、MMP1表达情况用于评估cHNSCC患者术后复发风险的效能。结果cHNSCC患者术后肿瘤组织PD-L1、MMP1阳性表达率高于癌旁组织(P<0.05)。不同临床分期cHNSCC患者术后PD-L1、MMP1阳性表达率差异有统计学意义(P<0.05)。复发组临床分期、术后放化疗情况、分化程度,PD-L1、MMP1表达情况与未复发组比较差异有统计学意义(P<0.05)。PD-L1、MMP1阳性表达是cHNSCC患者术后复发的危险因素(P<0.05)。PD-L1、MMP1联合预测cHNSCC患者术后复发的灵敏度、特异度分别为87.90%、79.59%。结论PD-L1、MMP1在cHNSCC患者肿瘤组织中呈高表达,是患者术后复发的独立危险因素,可作为评估术后复发风险的客观指标,具有较高临床应用价值。Objective To analyze the expression of programmed cell death protein ligand-1(PD-L1)and matrix metalloproteinase 1(MMP1)in patients with head and neck cutaneous squamous cell carcinoma(cHNSCC),and to analyze their correlation with postoperative Recurrence correlation.Methods A total of 173 patients with cHNSCC admitted to the hospital from May 2020 to August 2021 were enrolled in the study.The expression of PD-L1 and MMP1 in tumor tissues and adjacent tissues of cHNSCC patients resected during operation was detected.The expressions of PD-L1 and MMP1 in cHNSCC patients with different clinical stages and the clinicopathological data of cHNSCC patients with different postoperative recurrence were compared.The influencing factors of postoperative recurrence in cHNSCC patients were analyzed.The efficacy of PD-L1 and MMP1 expression in predicting the risk of postoperative recurrence in cHNSCC patients was analyzed.Results The positive expression rates of PD-L1 and MMP1 in postoperative tumor tissues of cHNSCC patients were higher than those in adjacent tissues(P<0.05).There were significant differences in the positive expression rates of PD-L1 and MMP1 among cHNSCC patients with different clinical stages(P<0.05).There were significant differences in clinical stage,postoperative radiotherapy and chemotherapy,degree of differentiation,and expression of PD-L1 and MMP1 between the recurrence group and the non-recurrence group(P<0.05).The positive expressions of PD-L1 and MMP1 were risk factors for postoperative recurrence in cHNSCC patients(P<0.05).The sensitivity and specificity of PD-L1 and MMP1 combined to predict postoperative recurrence in cHNSCC patients were 87.90%and 79.59%,respectively.Conclusion PD-L1 and MMP1 are highly expressed in tumor tissues of cHNSCC patients,which are independent risk factors for postoperative recurrence.They can be used as objective indicators to evaluate the risk of postoperative recurrence and have high clinical application value.

关 键 词：头颈部皮肤鳞状细胞癌 程序性细胞死亡蛋白配体-1 基质金属蛋白酶1 术后复发 

分 类 号：R446.8[医药卫生—诊断学]