脑脊液标志物在中枢神经系统淋巴瘤诊断和预测中的研究进展  

Research progress of cerebrospinal fluid markers in the diagnosis and prediction of central nervous system lymphoma

作　　者：彭余 冉隆荣 李莲 赵明宇 罗欣 陈双 张伟(综述) 杨再林(审校) PENG Yu;RAN Longrong;LI Lian;ZHAO Mingyu;LUO Xin;CHEN Shuang;ZHANG Wei;YANG Zailin(Chongqing University Cancer Hospital,Chongqing 400030,China)

机构地区：[1]重庆大学附属肿瘤医院血液肿瘤中心,重庆400030

出　　处：《国际检验医学杂志》2023年第4期490-495,共6页International Journal of Laboratory Medicine

基　　金：重庆市科卫联合医学科研项目(2021MSXM272)。

摘　　要：中枢神经系统淋巴瘤(CNSL)为侵袭性肿瘤,可累及大脑、脑膜、脊髓及眼睛,具有预后差,临床治疗效果不佳,病死率高等特点。目前脑组织活检虽是诊断CNSL的“金标准”,但存在手术风险大、易漏诊等不足。因此,亟需寻找可靠、获取方便、可动态反映淋巴瘤中枢神经系统浸润的生物学标志物,从而筛查出高危或早期淋巴瘤中枢神经系统浸润患者并及时给予预防性治疗或早期干预,从而降低病死率。本文基于当前的研究报道,对脑脊液的流式细胞免疫分型及细胞因子、基因突变、循环肿瘤DNA、微小RNA等生物学标志物在淋巴瘤中枢神经系统浸润诊断和预测中的价值进行综述。Central nervous system lymphoma(CNSL)is an aggressive tumor that can involve the brain,meninges,spinal cord and eyes,and is characterized by poor prognosis,poor clinical outcome and high mortality rate.Although brain tissue biopsy is currently the“gold standard”for the diagnosis of CNSL,there are shortcomings such as high surgical risk and easy to be misdiagnosed.Therefore,there is an urgent need to find reliable and easily accessible biological markers that can dynamically reflect infiltration of lymphoma in central nervous system,so that patients with high-risk or early infiltration of lymphoma in central nervous system can be screened and given timely preventive treatment or early intervention,thus reducing the mortality rate.This article reviewed the value of flow cytometric immunophenotyping of cerebrospinal fluid and biological markers such as cytokines,gene mutations,circulating tumor DNA,and microRNAs in the diagnosis and prediction lymphoma infiltration in central nervous system based on current research reports.

关 键 词：淋巴瘤 中枢神经系统浸润 细胞因子 

分 类 号：R446.14[医药卫生—诊断学]