壳聚糖负载碘催化合成α-氨基腈类衍生物  

Synthesis ofα-aminonitrile derivatives catalyzedby chitosan supported iodine

作　　者：黄宇 刘心韵 岑永文 刘雨东 尹晓刚[1] HUANG Yu;LIU Xin-yun;CEN Yong-wen;LIU Yu-dong;YIN Xiao-gang(School of Chemistry and Materials Science,Guizhou Normal University,Guiyang 550001,China;School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang 550025,China)

机构地区：[1]贵州师范大学化学与材料科学学院,贵州贵阳550001 [2]贵州医科大学药学院,贵州贵阳550025

出　　处：《化学研究与应用》2023年第2期303-310,共8页Chemical Research and Application

基　　金：贵州省科技厅科学技术基金项目(黔科合基础[2020]1Y030)资助。

摘　　要：以壳聚糖负载碘(CS/I2)作为催化剂,甲醇为溶剂,三甲基氰硅烷(TMSCN)、芳香醛、芳香胺为原料,一锅法合成了18种α-氨基腈衍生物。单因素控制变量法考察了反应时间、温度、催化剂用量、溶剂以及原料摩尔比对模板反应产率的影响。结果表明:在室温下CS/I2作催化剂,用量为苯甲醛物质的量的4.3%,甲醇为溶剂,反应时间10min,苯甲醛∶苯胺∶TMSCN=1.0∶1.0∶1.4的最优条件下,模型反应产率可达97.7%,催化剂循环三次后产率为85.8%,扩展衍生物产率为71.6~98.8%。Using chitosan supported iodine(CS/I2)as catalyst,methanol as solvent,trimethylcyanosilane(TMSCN),aromatic aldehydes and aromatic amines as starting materials,18α-aminonitrile derivatives were synthesized by one-pot method.The effects of reaction time,temperature,catalyst loading,solvent and molar ratio on the yield of template reaction were investigated by single factor control variable method.The results showed that CS/I2 was used as catalyst at room temperature,the amount of benzaldehyde was 4.3%mmol,methanol was used as solvent,reaction time 10 min,benzaldehyde∶aniline∶TMSCN=1.1∶1.1∶1.4 under the optimal conditions,the yield of the model reaction could reach 97.7%,the yield after three cycles of the catalyst was 85.8%,and the yield of the extended derivative was 71.6~98.8%.

关 键 词：壳聚糖负载碘 芳香醛 一锅法 α-氨基腈 

分 类 号：O625.1[理学—有机化学]